Evidence map›Paper›PMID 39314945›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Proteogenomic signature of risk of Alzheimer's disease and related dementia risk in individuals with a history of major depression disorder.

Breno Satler Diniz, Zhiduo Chen, David C Steffens, Luke Pilling, Richard H Fortinsky, George A Kuchel, Chia-Ling Kuo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Breno Satler DinizUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Zhiduo ChenUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
David C SteffensDepartment of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA.
Luke PillingEpidemiology and Public Health Group, Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.ORCID 0000-0002-3332-8454
Richard H FortinskyUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
George A KuchelUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Chia-Ling KuoUConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.

Funding

Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
NIA NIH HHS P30 AG067988
6 · The paper itself

Abstract

The mechanisms linking a history of major depressive disorder (MDD) to an increased risk of Alzheimer's disease and related dementia (ADRD) are not fully understood. Using the UK Biobank available proteomic and genomic data, we evaluated the biological mechanisms linking both conditions. In participants with a history of MDD at baseline (n=3,615), we found that plasma levels of NfL, GFAP, PSG1 were associated with higher risk (HR=1.38; 1.37; 1.34, respectively; all adjusted p-values<0.05), while VGF, GET3, and HPGDS were associated with lower risk of incident ADRD (n=150) (HR=0.73; 0.71; 0.66, respectively; all adjusted p-values<0.05) during a mean follow-up of 13.7 years (SD=2.2). Two-sample Mendelian randomization analysis using cis-pQTLs genetic instruments revealed that a lower protein expression of apolipoprotein E and higher IL-10 receptor subunit B were causally linked to incident ADRD. Finally, we developed a Proteomic Risk Score (PrRS

Indexed as

Alzheimer’s diseasedementiagenomicsinflammationMajor depressive disorderproteomics

Identifiers

PMID39314945
PMCPMC11419236

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.