Evidence map›Paper›PMID 39315853›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Electrochemical impedance spectroscopy unmasks high-risk atherosclerotic features in human coronary artery disease.

Michael Chen, Krit Suwannaphoom, Yas Sanaiha, Yuan Luo, Peyman Benharash, Michael C Fishbein, René R Sevag Packard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael ChenDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0003-0694-6641
Krit SuwannaphoomDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0009-0009-6036-829X
Yas SanaihaCardiovascular Outcomes Research Laboratories, University of California, Los Angeles, California, USA.ORCID 0000-0002-3976-5620
Yuan LuoState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, People's Republic of China.ORCID 0000-0003-3153-7495
Peyman BenharashCardiovascular Outcomes Research Laboratories, University of California, Los Angeles, California, USA.ORCID 0000-0002-4705-0262
Michael C FishbeinDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0002-6591-6306
René R Sevag PackardDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0002-8520-5843

Funding

Dissecting mechanisms of anthracycline-induced cardiotoxicityR56HL158569 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PACKARD, RENE R.S. · 2022 to 2022
$390k
Integrating 3-D Intravascular Sensors with Fractional Flow Reserve for Lipid-Rich PlaquesI01BX004558 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI PACKARD, RENE R.S. · 2020 to 2023
–
BLRD VA I01 BX004558HHS | National Institutes of Health (NIH) R56HL158569NHLBI NIH HHS R56 HL158569UC | University of California, Los Angeles (UCLA)U.S. Department of Veterans Affairs (VA) BX004558
6 · The paper itself

Abstract

Coronary plaque rupture remains the prominent mechanism of myocardial infarction. Accurate identification of rupture-prone plaque may improve clinical management. This study assessed the discriminatory performance of electrochemical impedance spectroscopy (EIS) in human cardiac explants to detect high-risk atherosclerotic features that portend rupture risk. In this single-center, prospective study, n = 26 cardiac explants were collected for EIS interrogation of the three major coronary arteries. Vessels in which advancement of the EIS catheter without iatrogenic plaque disruption was rendered impossible were not assessed. N = 61 vessels underwent EIS measurement and histological analyses. Plaques were dichotomized according to previously established high rupture-risk parameter thresholds. Diagnostic performance was determined via receiver operating characteristic areas-under-the-curve (AUC). Necrotic cores were identified in n = 19 vessels (median area 1.53 mm

Indexed as

Coronary Artery DiseaseCoronary VesselsDielectric SpectroscopyPlaque, AtheroscleroticAgedAtherosclerosisFemaleHumansMaleMiddle AgedProspective StudiesRisk Factorselectrochemical impedance spectroscopyfibrous caphigh‐risk plaquehuman coronary artery diseaseinflammationinvasive sensornecrotic core

Identifiers

PMID39315853
PMCPMC11728480

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.