Evidence map›Paper›PMID 39316674›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Normalization of Muc5b ameliorates airway mucus plugging during persistent

Mikayla Murphree-Terry, Johnathan D Keith, Ashley M Oden, Susan E Birket

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Airway mucus in infection.Frontiers in physiology · 2026
    Review
  3. Myeloperoxidase impairs mucociliary transport on human airway epithelium.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. iScience · 2025
    Article
  6. ERJ open research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mikayla Murphree-TerryDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0001-7390-9512
Johnathan D KeithGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Ashley M OdenDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Susan E BirketDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-6353-6596

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Susan Elizabeth Birket · 2007 to 2026
$23.0M
The Role of Airway Mucus in Infection and InflammationR01HL153079 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2021 to 2025
$2.2M
The Mechanisms Underlying Abnormal Mucus and its Clearance in the Cystic Fibrosis RatK08HL131867 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2017 to 2021
$637k
Cystic Fibrosis Foundation (CFF) BIRKET20A0Cystic Fibrosis Foundation (CFF) BIRKET20A0-KBoostCystic Fibrosis Foundation (CFF) BIRKET20G0Cystic Fibrosis Foundation (CFF) ROWE19R0HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1K08HL131867HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL153079HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 5P30DK072482NHLBI NIH HHS K08 HL131867NHLBI NIH HHS R01 HL153079NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

In cystic fibrosis, the airway gel-forming mucin MUC5B accumulates in the airways, preventing clearance of pathogens like

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorMucin-5BMucusPseudomonas aeruginosaPseudomonas InfectionsAnimalsCystic FibrosisMaleRatsCFTR protein, ratCystic Fibrosis Transmembrane Conductance RegulatorMucin-5Bairway infectionscystic fibrosismucinmucociliary clearancemucoinflammatory cycle

Identifiers

PMID39316674
PMCPMC11563644

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.