Evidence map›Paper›PMID 39316773›Full record

Trial reportAmerican journal of respiratory and critical care medicine2025

Ivacaftor for Chronic Obstructive Pulmonary Disease: Results from a Phase 2, Randomized Controlled Trial.

Kadambari Vijaykumar, George M Solomon, Jennifer Guimbellot, Edward P Acosta, Pradeep G Bhambhavni, Sharon White, Harrison Kim, S Vamsee Raju, Lawrence W Rasmussen, Necole Harris and 4 more

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Cystic Fibrosis: Huge Gains, but Still a Work in Progress.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Kadambari VijaykumarDepartment of Medicine.ORCID 0000-0001-6924-4335
George M SolomonDepartment of Medicine.
Jennifer GuimbellotGregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama; and.
Edward P AcostaDivision of Clinical Pharmacology, Department of Pharmacology and Toxicology, and.
Pradeep G BhambhavniDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Sharon WhiteDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Harrison KimDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
S Vamsee RajuDepartment of Medicine.
Lawrence W RasmussenGregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama; and.
Necole HarrisLung Health Center, Division of Pulmonary, Allergy and Critical Care Medicine.
Bo LiuGregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama; and.
Heather HathorneGregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama; and.
Steven M RoweDepartment of Medicine.ORCID 0000-0001-9045-0133
Mark T DransfieldDepartment of Medicine.ORCID 0000-0002-9207-1820

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
Translational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3M
Cystic Fibrosis Foundation ROWE22XX0/004507222NHLBI NIH HHS R35 HL135816NIDDK NIH HHS P30 DK072482NIH HHS P30DK072482NIH HHS R35HL135816
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AminophenolsPulmonary Disease, Chronic ObstructiveQuinolonesAgedCystic Fibrosis Transmembrane Conductance RegulatorDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment OutcomeAminophenolsCystic Fibrosis Transmembrane Conductance RegulatorivacaftorQuinolonesCFTR dysfunctionCFTR modulatorschronic bronchitisCOPDivacaftor

Identifiers

PMID39316773
PMCPMC12091003

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.