Evidence map›Paper›PMID 39317998›Full record

ArticleCurrent pharmaceutical design2025

Bioactive Macromolecule-mediated Biogenic FeONPs Attenuate Inflammation in Atherosclerotic Rat by Activating PI3K/Akt/eNOS Pathway.

Qing Du, Bo Chen, Xiaohan Yang, Hecheng Zhu, Syed Shams Ul Hassan, Qiang Liu

Abstract read
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Article in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qing DuDepartment of Emergency, The Fourth People's Hospital of Jinan, Shifan Road, No. 50, Jinan 250031, China.
Bo ChenDepartment of Cardiology, The Fourth People's Hospital of Jinan, Shifan Road, No. 50, Jinan 250031, China.
Xiaohan YangDepartment of Cardiology, The Fourth People's Hospital of Jinan, Shifan Road, No. 50, Jinan 250031, China.
Hecheng ZhuDepartment of Cardiology, The Fourth People's Hospital of Jinan, Shifan Road, No. 50, Jinan 250031, China.
Syed Shams Ul HassanSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 210000, China.
Qiang LiuDepartment of Cardiology, The Fourth People's Hospital of Jinan, Shifan Road, No. 50, Jinan 250031, China.

Funding

Clinical Medical Innovation Program from Jinan Science and Technology Bureau 202134052Natural Science Foundation of Shandong Province ZR2020QH015
6 · The paper itself

Abstract

introductionAtherosclerosis refers to the thickening and hardening of artery walls. In our latest experiment, we utilized environmentally friendly techniques to produce multifunctional iron oxide nanoparticles (FeONPs) aimed at reducing inflammation in rats with atherosclerosis.

methodsThe formulation was synthesized using curcumin (as the potent bioactive molecule) and was characterized. We assessed the

resultsThe crystallinity and magnetic behavior confirmed the magnetic properties of the FeONPs. The DPPH assay exhibited the dose-dependent radical scavenging characteristics of FeONPs. In the animal experiments, significant upregulation of the studied genes was noticed in treated groups 2 and 3 compared to treated group 1. Moreover, the expression of PI3K/eNOS/Akt was greater in treated group 3 than in treated group 2. These results indicate a dose-dependent elevation in target gene expression.

conclusionNevertheless, the variation in gene expression between the negative control and the untreated control was not statistically significant (p > 0.05) across all genes.

Indexed as

AtherosclerosisInflammationMagnetic Iron Oxide NanoparticlesNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsMaleMiceRatsSignal TransductionNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktantioxidant.atheroscleroticBioactive macromoleculebioactive moleculenanoparticlesPI3K/Akt/Enos pathway

Identifiers

PMID39317998

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.