Evidence map›Paper›PMID 39318010›Full record

ReviewEndocrine, metabolic & immune disorders drug targets2025

A Toluene-induced Infundibulo-neuro-hypophysitis: Presentation of a New Cause of Hypophysitis Secondary to Toxic Exposure and Review on Toluene Inhalation Endocrine Effects.

Flavia Costanza, Antonella Giampietro, Tommaso Tartaglione, Flavia Angelini, Simona Gaudino, Laura De Marinis, Alfredo Pontecorvi, Sabrina Chiloiro, Antonio Bianchi

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In one paragraph

Review in Endocrine, metabolic & immune disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Flavia CostanzaDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Antonella GiampietroDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Tommaso TartaglioneDepartment of Imaging, Radiation Therapy and Hematology, Catholic University of the Sacred Heart, Fondazione Policlinico Univer-sitario A. Gemelli IRCCS, Rome, Italy.
Flavia AngeliniDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Simona GaudinoDepartment of Imaging, Radiation Therapy and Hematology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Laura De MarinisDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Alfredo PontecorviDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Sabrina ChiloiroDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Antonio BianchiDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHypophysitis is a rare inflammatory disorder of the pituitary gland. Symptoms and signs of hypophysitis can be various, progressing insidiously, and its recognition may be challenging. CASE PRESENTATION: We report the clinical history and therapeutic management of a 59-year-old man diagnosed with arginine vasopressin deficiency (AVP-D) due to an infundibulo-neurohypophysitis (INH) that occurred after the patient had inhaled spray film containing toluene. In consideration of the clinical signs and radiological imaging suggestive of INH, therapy with desmopressin and corticosteroids was instituted, with gradual improvement of polyuria and resolution of the radiological features of INH.

conclusionTo our knowledge, we described the first case of INH, manifested with AVP-D, secondary to toluene exposure. In addition, the endocrine effects of toluene inhalation were discussed. Finally, given the scarcity of data available, an overview of all the known toxic substances inducing AVP-D was also provided.

Indexed as

HypophysitisInhalation ExposureTolueneAdministration, InhalationDeamino Arginine VasopressinHumansMaleMiddle AgedDeamino Arginine VasopressinToluenearginine vasopressin deficiencydiabetes insipidus.endocrine effectsNeuro-hypophysitissecondary hypophysitistoluene exposuretoluene inhalationtoxic exposuretoxic-induced

Identifiers

PMID39318010

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.