Evidence map›Paper›PMID 39320485›Full record

ArticleEuropean journal of applied physiology2025

Environmental study and stress-related biomarkers modifications in a crew during analog astronaut mission EMMPOL 6.

T A Giacon, Simona Mrakic-Sposta, G Bosco, A Vezzoli, Cinzia Dellanoce, M Campisi, M Narici, M Paganini, B Foing, A Kołodziejczyk and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

T A GiaconDepartment of Biomedical Sciences, University of Padova, Via Marzolo 3, 35131, Padua, Italy.ORCID http://orcid.org/0000-0002-1155-0628
Simona Mrakic-SpostaInstitute of Clinical Physiology, National Research Council (IFC-CNR), Piazza dell'Ospedale Maggiore, 3, 20162, Milan, Italy. simona.mrakicsposta@cnr.it.ORCID http://orcid.org/0000-0001-7359-2690
G BoscoDepartment of Biomedical Sciences, University of Padova, Via Marzolo 3, 35131, Padua, Italy. gerardo.bosco@unipd.it.
A VezzoliInstitute of Clinical Physiology, National Research Council (IFC-CNR), Piazza dell'Ospedale Maggiore, 3, 20162, Milan, Italy.ORCID http://orcid.org/0000-0002-0277-163X
Cinzia DellanoceInstitute of Clinical Physiology, National Research Council (IFC-CNR), Piazza dell'Ospedale Maggiore, 3, 20162, Milan, Italy.ORCID http://orcid.org/0000-0002-0750-6261
M CampisiOccupational Medicine, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.ORCID http://orcid.org/0000-0002-7372-4136
M NariciDepartment of Biomedical Sciences, University of Padova, Via Marzolo 3, 35131, Padua, Italy.ORCID http://orcid.org/0000-0003-0167-1845
M PaganiniDepartment of Biomedical Sciences, University of Padova, Via Marzolo 3, 35131, Padua, Italy.ORCID http://orcid.org/0000-0002-7556-6928
B FoingLUNEX EuroMoonMars, and EuroSpaceHub Academy, Leiden Observatory, Leiden, Netherlands.ORCID http://orcid.org/0000-0002-5110-1026
A KołodziejczykSpace Technology Centre, AGH University of Science and Technology, Kraków, Poland.ORCID http://orcid.org/0000-0002-2209-332X
M MartinelliInstitute of Science and Information Technologies "Alessandro Faedo", National Research Council (ISTI-CNR), Via G. Moruzzi 1, 56124, Pisa, Italy.ORCID http://orcid.org/0000-0001-7419-5099
S PavanelloOccupational Medicine, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.ORCID http://orcid.org/0000-0002-5229-9900

Funding

Bird SP BIRD 204020
6 · The paper itself

Abstract

purposeHuman presence in space is increasingly frequent, but we must not forget that it is a hostile environment. We aimed to study the characteristics of experimental scenarios, to obtain data on human response to isolation, disruption of circadian rhythm and high levels of psychophysical stress.

methodsIn these experiments, we evaluated stress response in five young healthy subjects inside an earth-based moon-settlement-like habitat during a 1-week long analog astronaut mission. Wearable devices were used to monitor daily step count of the subjects, physical activity, heart rate during physical exercise and at rest, and sleep parameters. From saliva and urine samples collected every day at awakening, we studied oxy-inflammation biomarkers and hormones (stress and appetite) were studied too.

resultsAt the end of the week, all subjects revealed an increase in oxidative stress and cortisol levels but no inflammation biomarkers variations, in conjunction with increasing time/daily exercise. Furthermore, a significant decrease in hours of sleep/day, sleep quality, and REM phase of sleep was recorded and correlated with the increase of reactive oxygen species.

conclusionOxidative stress increased in a short period of time and may be attributed to the influence of psychological stress during confinement, as well as increased exercise and decreased amount of sleep. On a long-term basis, this could impact performance.

Indexed as

AstronautsOxidative StressSpace FlightStress, PsychologicalAdultBiomarkersCircadian RhythmExerciseFemaleHeart RateHumansHydrocortisoneMaleSalivaSleepBiomarkersHydrocortisoneConfinementCortisolNon-invasive methodsOxy-inflammationSpace exploration

Identifiers

PMID39320485
PMCPMC11753359

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.