Evidence map›Paper›PMID 39320962›Full record

ArticleMolecular and cellular biology2024

Expression of Smyd1b_tv1 by Alternative Splicing in Cardiac Muscle is Critical for Sarcomere Organization in Cardiomyocytes and Heart Function.

Rui Xu, Siping Li, Chien-Ju Chien, Yongwang Zhong, Huanhuan Xiao, Shengyun Fang, Shaojun Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rui XuDepartment of Biochemistry and Molecular Biology, Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Siping LiDepartment of Biochemistry and Molecular Biology, Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Chien-Ju ChienDepartment of Biochemistry and Molecular Biology, Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yongwang ZhongCenter for Biomedical Engineering, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Huanhuan XiaoDepartment of Biochemistry and Molecular Biology, Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shengyun FangCenter for Biomedical Engineering, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shaojun DuDepartment of Biochemistry and Molecular Biology, Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Funding

Molecular regulation of muscle development by Smyd1R01AR072703 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI DU, SHAOJUN · 2018 to 2023
$1.7M
Cryo Upgrade of UMB EM Core FacilityS10RR026870 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI HSIA, RU-CHING · 2010 to 2010
$421k
NCRR NIH HHS S10 RR026870NIAMS NIH HHS R01 AR072703
6 · The paper itself

Abstract

Smyd1, a member of the Smyd lysine methyltransferase family, plays an important role in myofibrillogenesis of skeletal and cardiac muscles. Loss of Smyd1b (a Smyd1 ortholog) function in zebrafish results in embryonic death from heart malfunction.

Indexed as

Alternative SplicingMyocytes, CardiacProtein IsoformsSarcomeresZebrafishZebrafish ProteinsAnimalsCell DifferentiationGene Expression Regulation, DevelopmentalHeartHistone-Lysine N-MethyltransferaseMuscle DevelopmentMuscle, SkeletalMyocardiumHistone-Lysine N-MethyltransferaseProtein IsoformsSmyD1a protein, zebrafishZebrafish Proteinsalternative splicingcardiomyocytesarcomereSmyd1

Identifiers

PMID39320962
PMCPMC11583600

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.