Evidence map›Paper›PMID 39321303›Full record

ArticleScience advances2024

Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate.

Nian Zhang, Dinesh Dhumal, Shanny Hsuan Kuo, Shi Qian Lew, Pankaj D Patil, Raleb Taher, Sanika Vaidya, Christina Galanakou, Abdechakour Elkihel, Myung Whan Oh and 9 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Antimicrobial Cyclic Peptidomimetics.Macromolecular rapid communications · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
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  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nian ZhangFaculty of Health Sciences, University of Macau, Taipa, Macau, China.ORCID 0009-0008-0368-9436
Dinesh DhumalAix-Marseille Universite, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, "Equipe Labellisee Ligue Contre le Cancer," 13288 Marseille, France.ORCID 0000-0002-3486-1859
Shanny Hsuan KuoDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-8924-6960
Shi Qian LewDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0009-0001-6534-5443
Pankaj D PatilAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Raleb TaherAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Sanika VaidyaAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Christina GalanakouAix-Marseille Universite, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, "Equipe Labellisee Ligue Contre le Cancer," 13288 Marseille, France.
Abdechakour ElkihelAix-Marseille Universite, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, "Equipe Labellisee Ligue Contre le Cancer," 13288 Marseille, France.ORCID 0000-0001-9559-1613
Myung Whan OhDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-7637-0644
Sook Yin ChongDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0009-0000-0061-8677
Domenico MarsonMolecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, Trieste, Italy.ORCID 0000-0003-1839-9868
Jun ZhengFaculty of Health Sciences, University of Macau, Taipa, Macau, China.ORCID 0000-0001-6329-4518
Oleg RouvinskiAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.ORCID 0009-0005-5770-7562
Williams O AbolarinAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.ORCID 0009-0006-4852-0314
Sabrina PriclMolecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, Trieste, Italy.ORCID 0000-0001-8380-4474
Gee W LauDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-7962-3950
Leo Tsz On LeeFaculty of Health Sciences, University of Macau, Taipa, Macau, China.ORCID 0000-0003-3691-478X
Ling PengAix-Marseille Universite, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, "Equipe Labellisee Ligue Contre le Cancer," 13288 Marseille, France.ORCID 0000-0003-3990-5248

Funding

Controlling bactermic pneumococcal pneumonia with synthetic dominant-negative competence peptidesR01HL142626 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LAU, GEE W, TALGAN, YIFTAH · 2019 to 2022
$2.0M
NHLBI NIH HHS R01 HL142626
6 · The paper itself

Abstract

The rapid emergence and spread of multidrug-resistant bacterial pathogens require the development of antibacterial agents that are robustly effective while inducing no toxicity or resistance development. In this context, we designed and synthesized amphiphilic dendrimers as antibacterial candidates. We report the promising potent antibacterial activity shown by the amphiphilic dendrimer

Indexed as

Anti-Bacterial AgentsDendrimersPhosphatidylglycerolsAcinetobacter baumanniiAnimalsCell MembraneEscherichia coliMicrobial Sensitivity TestsAnti-Bacterial AgentsDendrimersPhosphatidylglycerols

Identifiers

PMID39321303
PMCPMC11423894

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.