ArticleEMBO molecular medicine2024
RIG-I is an intracellular checkpoint that limits CD8
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Article in EMBO molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Dynamic remodeling of the pancreas immune landscape in obesity.Nature communications · 2026Article
- Depletion of the RNA-Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- RIG-I Stimulation Enhances the Effector Function and Proliferation of Primary Human CD8+ T Cells.International journal of molecular sciences · 2026Article
- mRNA-based CAR T cell engineering: Unmodified mRNA enables high CAR expression without innate immune activation in T cells.Molecular therapy. Nucleic acids · 2026Article
- T cell-intrinsic PRR signaling in immunity and pathology.Acta biochimica et biophysica Sinica · 2026Review
- Negative regulators antagonizing antitumor innate immune pathways in lung cancer immune evasion.Frontiers in immunology · 2026Review
- CAR T cell engineering impacts antigen-independent activation and co-inhibition.Molecular therapy. Methods & clinical development · 2025Article
- Overcoming Immune Therapy Resistance in Cancer Through Innate Immune Reprogramming.International journal of molecular sciences · 2025Review
- Leveraging innate immune signals in CD8+ T cells to boost antitumor immunity.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Xiaobing Duan *Guangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China. duanxb3@mail3.sysu.edu.cn.ORCID http://orcid.org/0000-0002-1629-6497
Jiali Hu *Guangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.ORCID http://orcid.org/0000-0001-9425-6987
Yuncong Zhang *Guangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Xiaoguang ZhaoGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Mingqi YangGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Taoping SunZhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.ORCID http://orcid.org/0000-0002-6412-5166
Siya LiuThe Third People's Hospital of Zhuhai, Zhuhai, 519000, China.
Xin ChenGene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, 528225, China.
Juan FengGene Editing Technology Center of Guangdong Province, School of Medicine, Foshan University, Foshan, 528225, China.
Wenting LiGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Ze YangGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Yitian ZhangGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.ORCID http://orcid.org/0000-0001-8451-7143
Xiaowen LinGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Dingjie LiuGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Ya MengGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Guang YangGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Qiuping LinZhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Guihai ZhangDepartment of Oncology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.ORCID http://orcid.org/0000-0002-4661-8864
Haihong LeiDepartment of Radiation Oncology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Zhengsheng YiDepartment of Radiation Oncology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Yanyan LiuGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Xiaobing LiangGuangdong Huixin Life Science Co., Ltd., Zhuhai, 519000, China.
Yujuan WuZhuhai Central Blood Station, Zhuhai, 519000, China.
Wenqing DiaoZhuhai Central Blood Station, Zhuhai, 519000, China.
Zesong LiGuangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumours, Shenzhen Key Laboratory of Genitourinary Tumour, Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), Shenzhen, China.ORCID http://orcid.org/0000-0003-0975-4434
Haihai LiangGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.ORCID http://orcid.org/0000-0003-4446-7035
Meixiao ZhanGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China.
Hong-Wei SunGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China. shongw@mail3.sysu.edu.cn.ORCID http://orcid.org/0000-0001-6236-2064
Xian-Yang LiGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China. lixianyang@ext.jnu.edu.cn.ORCID http://orcid.org/0000-0003-4163-5283
Ligong LuGuangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 519000, China. luligong1969@jnu.edu.cn.ORCID http://orcid.org/0000-0002-7850-7640
Funding
GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province () 2020A1515110013GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province () 2021A1515110561GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province () 2021A1515220187GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province () 2024A1515012563Guangdong Provincial Key Laboratory of Construction Foundation () 2021B1212040004MOST | National Natural Science Foundation of China (NSFC) 32200936MOST | National Natural Science Foundation of China (NSFC) 32470961MOST | National Natural Science Foundation of China (NSFC) 8204415MOST | National Natural Science Foundation of China (NSFC) 82103306MOST | National Natural Science Foundation of China (NSFC) 82103433MOST | National Natural Science Foundation of China (NSFC) 82230067MOST | National Natural Science Foundation of China (NSFC) 82304589Scientific Research start up Project of Zhuhai People's Hospital 2021KYQD-04Shenzhen Municipal Science and Technology Innovation Council | Shenzhen Science and Technology Innovation Program () JCYJ20220818101808018the Science and Technology Planning Project of Guangzhou SL2024A03J00598
Abstract
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor involved in innate immunity, but its role in adaptive immunity, specifically in the context of CD8
Indexed as
CD8-Positive T-LymphocytesDEAD Box Protein 58AnimalsHumansImmune Checkpoint InhibitorsImmunotherapyMiceMice, Inbred C57BLNeoplasmsReceptors, ImmunologicSignal TransductionDdx58 protein, mouseDEAD Box Protein 58Immune Checkpoint InhibitorsReceptors, ImmunologicRIGI protein, humanAKT/Glycolysis Signalling PathwayCD8+ T cellsImmune CheckpointImmunotherapyRIG-I
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.