ArticleDiabetic medicine : a journal of the British Diabetic Association2025
Association of early post-transplant hyperglycaemia and diabetes mellitus on outcomes following heart transplantation.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Transplant Recipients: A Systematic Review and Meta-analyses.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Pooled it
- Donor diabetes status impacts long-term survival in diabetic heart transplant recipients.JHLT open · 2026Article
- The Clinical Impact of Early Steroid Withdrawal on Diabetes Mellitus After Liver Transplantation: A Population-Based Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Electronic nose for detecting abnormal glucose metabolism in heart transplant recipients.Cardiovascular diabetology · 2025Article
- METAB-HTX: prospective, longitudinal cohort study evaluating cardiac and systemic metabolism after heart transplantation.ESC heart failure · 2025Article
- Sodium glucose cotransporter 2 inhibitors are associated with renal stabilization in heart transplantation.JHLT open · 2025Article
- Association of early post-transplant hyperglycaemia and diabetes mellitus on outcomes following heart transplantation.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
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Authors and funding
5 authors.
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Abstract
aimsEarly post-transplant hyperglycaemia (EPTH) and post-transplant diabetes mellitus (PTDM) are common following solid organ transplantation and may be associated with adverse outcomes. We studied the prevalence of EPTH and cumulative 5-year prevalence of PTDM in a modern cohort of heart transplant recipients who were free from diabetes at baseline as well as the association of EPTH, PTDM and pre-transplant T2DM with adverse transplant-related outcomes.
methodsRetrospective cohort study of heart transplant recipients followed for 5 years at a single centre in Sydney, Australia.
resultsA total of 141 patients were included, of whom 25 had pre-existing type 2 diabetes mellitus (T2DM) and 116 were free from diabetes at baseline. In patients without pre-existing T2DM, 88 of 116 (76%) experienced EPTH, which was associated with higher rates of acute rejection and hospitalizations, and lower 5-year survival. PTDM developed in 45 of 116 (39%) patients, all of whom had experienced EPTH. Both PTDM and pre-existing T2DM were associated with increased rates of graft rejection and hospitalization, and greater than three-fold increased likelihood of death compared to patients that remained free from diabetes.
conclusionEPTH and PTDM are highly prevalent following cardiac transplantation. EPTH develops within days of transplant and is strongly associated with progression to PTDM. Pre-existing T2DM, PTDM and EPTH are associated with greater hospitalization, increased episodes of rejection and worse 5-year survival compared to patients who remained free from diabetes during follow-up.
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