Evidence map›Paper›PMID 39323747›Full record

ArticleRegenerative biomaterials2024

Cross-linking manipulation of waterborne biodegradable polyurethane for constructing mechanically adaptable tissue engineering scaffolds.

Nan Sheng, Weiwei Lin, Jingjing Lin, Yuan Feng, Yanchao Wang, Xueling He, Yuanyuan He, Ruichao Liang, Zhen Li, Jiehua Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nan ShengCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.
Weiwei LinCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.
Jingjing LinCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.
Yuan FengCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.
Yanchao WangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, China.
Xueling HeLaboratory Animal Center, Sichuan University, Chengdu 610041, China.
Yuanyuan HeCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.
Ruichao LiangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, China.ORCID https://orcid.org/0000-0002-0888-7510
Zhen LiCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.
Jiehua LiCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.
Feng LuoCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.ORCID https://orcid.org/0000-0001-6645-9496
Hong TanCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.ORCID https://orcid.org/0000-0003-0695-1619

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical adaptation of tissue engineering scaffolds is critically important since natural tissue regeneration is highly regulated by mechanical signals. Herein, we report a facile and convenient strategy to tune the modulus of waterborne biodegradable polyurethanes (WBPU) via cross-linking manipulation of phase separation and water infiltration for constructing mechanically adaptable tissue engineering scaffolds. Amorphous aliphatic polycarbonate and trifunctional trimethylolpropane were introduced to polycaprolactone-based WBPUs to interrupt interchain hydrogen bonds in the polymer segments and suppress microphase separation, inhibiting the crystallization process and enhancing covalent cross-linking. Intriguingly, as the crosslinking density of WBPU increases and the extent of microphase separation decreases, the material exhibits a surprisingly soft modulus and enhanced water infiltration. Based on this strategy, we constructed WBPU scaffolds with a tunable modulus to adapt various cells for tissue regeneration and regulate the immune response. As a representative application of brain tissue regeneration model in vivo, it was demonstrated that the mechanically adaptable WBPU scaffolds can guide the migration and differentiation of endogenous neural progenitor cells into mature neurons and neuronal neurites and regulate immunostimulation with low inflammation. Therefore, the proposed strategy of tuning the modulus of WBPU can inspire the development of novel mechanically adaptable biomaterials, which has very broad application value.

Indexed as

central nervous repairmechanical adaptationmodulustissue engineering scaffoldwaterborne polyurethane

Identifiers

PMID39323747
PMCPMC11422185

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.