Evidence map›Paper›PMID 39323877›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2024

Prognostic Factors and Epidemiology of Amyotrophic Lateral Sclerosis in Southeastern United States.

Erica Engelberg-Cook, Jaimin S Shah, Andre Teixeira da Silva Hucke, Diana V Vera-Garcia, Jany E Dagher, Megan H Donahue, Veronique V Belzil, Björn Oskarsson

Abstract read
In one paragraph

Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Metabolomic analyses of amyotrophic lateral sclerosis, muscle cramps, and TJ-68 treatment.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erica Engelberg-CookDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL.
Jaimin S ShahDepartment of Neurology, Mayo Clinic, Jacksonville, FL.
Andre Teixeira da Silva HuckeDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL.
Diana V Vera-GarciaDepartment of Laboratory Medicine and Pathology, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Jacksonville, FL.
Jany E DagherResearch Administration, Mayo Clinic, Jacksonville, FL.
Megan H DonahueResearch Administration, Mayo Clinic, Jacksonville, FL.
Veronique V BelzilDepartment of Neurology, Vanderbilt Medical Center, Nashville, TN.
Björn OskarssonDepartment of Neurology, Mayo Clinic, Jacksonville, FL.

Funding

Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTDR01AG067151 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELZIL, VERONIQUE, KELLIS, MANOLIS · 2021 to 2025
$3.7M
Single-cell multi-region transcriptional and epigenomic dissection of VCID.RF1NS129032 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HEIMAN, MYRIAM, KELLIS, MANOLIS · 2022 to 2022
$3.1M
Single-cell multi-region transcriptional and epigenomic dissection of VCID.R01NS129032 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Myriam Heiman, Manolis Kellis · 2025 to 2026
$2.1M
NIA NIH HHS R01 AG067151NINDS NIH HHS R01 NS129032NINDS NIH HHS RF1 NS129032
6 · The paper itself

Abstract

Objective: To assess the performance of known survival predictors and evaluate their stratification capability in patients with amyotrophic lateral sclerosis (ALS). Patients and Methods: We analyzed demographic and clinical variables collected at the Mayo Clinic, Florida ALS center during the first clinical visit of 1442 (100%) patients with ALS. Results: Our cohort had a median (interquartile range [IQR]) age at diagnosis of 64.8 (57-72) years; 1350 (92%) were non-Hispanic White; and 771 (53.5%) were male. The median (IQR) diagnostic delay was 10.1 (6-18) months, body mass index was 25.4 (23-49), and forced vital capacity was 72% (52%-87%). Approximately 12% of patients tested carried a pathologic Conclusion: Although results obtained from our cohort are consistent with other reports (eg, men with spinal onset experience a longer survival than women with bulbar onset), they remind us of the complexity of the disease's natural history and the limited prognostic power of the most common clinical predictors.

Identifiers

PMID39323877
PMCPMC11422511

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.