Evidence map›Paper›PMID 39323992›Full record

ArticleFrontiers in oncology2024

The potential of retinoic acid receptors as prognostic biomarkers and therapeutic targets in gastric cancer.

Silvio Ken Garattini, Debora Basile, Valli' De Re, Giulia Brisotto, Gianmaria Miolo, Vincenzo Canzonieri, Giuseppe Aprile, Carla Corvaja, Silvia Buriolla, Enrico Garattini and 1 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The influence ofFrontiers in immunology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Silvio Ken GarattiniDepartment of Oncology, ASUFC University Hospital, Udine, Italy.
Debora BasileDepartment of Medical Oncology, San Giovanni di Dio Hospital, Crotone, Italy.
Valli' De ReImmunopathology and Cancer Biomarkers/Bio-Proteomics Facility, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Giulia BrisottoImmunopathology and Cancer Biomarkers/Bio-Proteomics Facility, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Gianmaria MioloDepartment of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Vincenzo CanzonieriPathology Unit, IRCCS CRO National Cancer Institute, Aviano, Italy.
Giuseppe AprileDepartment of Oncology, University and General Hospital, Udine, Italy.
Carla CorvajaDivision of Thoracic Oncology, European Institute of Oncology (IEO) IRCCS, Milano, Italy.
Silvia BuriollaDepartment of Oncology, ASUFC University Hospital, Udine, Italy.
Enrico GarattiniDepartment of Biochemistry and Molecular Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
Fabio PuglisiDepartment of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gastric cancer is a heterogeneous collection of tumors characterized by low survival rates. All-trans retinoic acid (retinoic-acid) is a clinically useful therapeutic agent belonging to the chemical family of retinoids, which consists of both natural and synthetic derivatives of vitamin-A. Retinoids are essential components of the normal diet and they regulate different physiological processes. From a therapeutic point of view, retinoic-acid is the first example of clinically useful differentiating agent. Indeed, the differentiating properties of this compound have promoted the use of retinoic-acid as a standard of care in Acute-Promyelocytic-Leukemia, a rare form of acute myeloid leukemia. In this study, we determine the RNA expression of the six isoforms of Methods: In this single institution and retrospective Results: Our data demonstrate ubiquitous expression of the Conclusions: In gastric cancer, high expression levels of

Indexed as

gastric cancerprognosticbiomarkersretinoic-acid-receptorsretrospective-clinical-studytherapeutic-targets

Identifiers

PMID39323992
PMCPMC11422079

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.