ReviewInternational journal of cardiology. Heart & vasculature2024
Real-world evidence of direct oral anticoagulants in patients with atrial fibrillation and cancer: A
Review in International journal of cardiology. Heart & vasculature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of periodontal disease with risk atrial fibrillation: systematic review.BMC oral health · 2025Pooled it
- Recent highlights from the International Journal of Cardiology Heart & Vasculature: thrombosis and antithrombotic therapy across the cardiovascular continuum.International journal of cardiology. Heart & vasculature · 2026Article
- Real-world safety and clinical outcomes of apixaban in patients with cancer and atrial fibrillation.Frontiers in cardiovascular medicine · 2026Article
- Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2025Article
- Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2025Article
- Risk of atrial fibrillation in patients with inflammatory bowel disease: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Several observational cohort studies have been conducted to investigate the effectiveness and safety of direct oral anticoagulants (DOACs) compared with vitamin K antagonists (VKAs) in patients who have both atrial fibrillation (AF) and cancer. Herein, we conducted a Methods: A comprehensive search strategy was performed in PubMed and Embase until February 2024 for studies that enrolled AF patients with cancer who received DOACs or VKAs. The adjusted risk ratios (RRs) and 95% confidence intervals (CIs) of each outcome were extracted and pooled by a random-effects model. Results: Seven observational cohort studies were eligible for data extraction. The random-effects model analysis indicated that compared with VKA use, the use of DOACs was significantly associated with reduced risks of stroke or systemic embolism (RR=0.79, 95 % CI 0.64---0.97), major bleeding (RR=0.84, 95 % CI 0.71---0.99), intracranial bleeding (RR=0.61, 95 % CI 0.54---0.69), and gastrointestinal bleeding (RR=0.87, 95 % CI 0.80---0.95) in AF patients with concurrent cancer. Conclusions: Compared with VKAs, the use of DOACs was associated with decreased risks of thrombotic and bleeding events in AF patients with cancer. Data from real-world scenarios support the use of DOACs as a favorable treatment option for this specific patient population.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.