Evidence map›Paper›PMID 39325169›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2025

Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways.

Kate R Oppegaard, Yvette P Conley, Steven Paul, Bruce Cooper, Carolyn S Harris, Joosun Shin, Lisa Morse, Jon D Levine, Frances Cartwright, Ritu Roy and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kate R OppegaardDana-Farber Cancer Institute, University of Massachusetts, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6358-6315
Yvette P ConleySchool of Nursing, University of Pittsburg, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-1784-6067
Steven PaulSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.ORCID http://orcid.org/0000-0002-3731-683X
Bruce CooperSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.ORCID http://orcid.org/0000-0001-8932-4113
Carolyn S HarrisSchool of Nursing, University of Pittsburg, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7080-4990
Joosun ShinThe Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6883-4448
Lisa MorseSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.ORCID http://orcid.org/0000-0001-9490-8906
Jon D LevineSchool of Medicine, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0681-5545
Frances CartwrightMount Sinai Health System, New York, NY, USA.
Ritu RoySchool of Medicine, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2065-7846
Michelle MeliskoSchool of Medicine, University of California, San Francisco, CA, USA.
Kord M KoberSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.ORCID http://orcid.org/0000-0001-9732-3321
Marilyn J HammerThe Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9561-6144
Christine MiaskowskiSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA. chris.miaskowski@ucsf.edu.ORCID http://orcid.org/0000-0001-5170-2027

Funding

UMass Boston-DF/HCC U54 Partnership (2 of 2)U54CA156734 · NCI · UNIVERSITY OF MASSACHUSETTS BOSTON · PI Jan Mutchler · 2010 to 2026
$24.9M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics ApproachR37CA233774 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOBER, KORD MICHAEL · 2019 to 2025
$4.8M
Characterization of the Symptom Experience of Patients with Cutaneous Melanoma Receiving Immune Checkpoint Inhibitor TherapyR00CA286967 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carolyn Stigge Harris · 2025 to 2026
$402k
Influence of Social Determinants of Health and Epigenomics on Psychological Symptom Cluster SeverityK99CA286967 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRIS, CAROLYN STIGGE · 2024 to 2025
$323k
NCI NIH HHS CA134900NCI NIH HHS CA156734NCI NIH HHS CA233774NCI NIH HHS CA286967NCI NIH HHS K99 CA286967NCI NIH HHS R00 CA286967NCI NIH HHS R01 CA134900NCI NIH HHS R37 CA233774NCI NIH HHS U54 CA156734
6 · The paper itself

Abstract

backgroundCancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI.

objectivesUsing a data-driven approach, the study purpose was to evaluate for perturbed pathways associated with membership in the High versus the Low CRCI profiles.

methodsPatients completed the Attentional Function Index six times over two cycles of chemotherapy. Using findings from a previous latent profile analysis, subgroups of patients with high versus low levels of CRCI were evaluated (i.e., High versus Low CRCI profiles). Gene expression was quantified using either ribonucleic (RNA)-sequencing or microarray analyses and pathway impact analyses were performed. Signaling pathways were defined using the Kyoto Encyclopedia of Genes and Genomes database.

resultsA total of 508 patients had data available for analysis. Of the 261 patients in the RNA-sequencing sample, 48.7% were in the High class and 51.3% were in the Low class. Of the 247 patients the microarray sample, 46.6% were in the High class and 53.4% were in the Low class. Pathway impact analyses identified seven perturbed pathways related to neurotransmission (i.e., glutamatergic synapse, GABAergic synapse, dopaminergic synapse, serotonergic synapse, long-term depression, cholinergic synapse, retrograde endocannabinoid signaling).

conclusionsThis study is the first to describe associations between self-reported CRCI in patients receiving chemotherapy for breast, gastrointestinal, gynecological, or lung cancer and seven neurotransmission pathways. These findings provide new insights into potential targets for mechanistically based interventions.

Indexed as

Chemotherapy-Related Cognitive ImpairmentCognitive DysfunctionNeoplasmsSynaptic TransmissionAdultAgedFemaleHumansMaleMiddle AgedSelf ReportSignal TransductionCancerChemotherapy-related cognitive impairmentCognitionGene expressionNeurotransmissionPathway analysisPatient-reported outcomes

Identifiers

PMID39325169
PMCPMC11785672

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.