Evidence map›Paper›PMID 39327092›Full record

ArticlePhysiological reports2024

Macrophages modulate skeletal muscle wasting and recovery in acute lung injury in mice.

Jennifer T W Krall, Lanazha Belfield, Claire Strysick, Chun Liu, Lina Purcell, Renee Stapleton, Michael Toth, Matthew Poynter, Xuewei Zhu, Kevin Gibbs and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer T W KrallSection on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0001-9847-7234
Lanazha BelfieldSection on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Claire StrysickSection on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Chun LiuSection on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Lina PurcellSection on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Renee StapletonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.
Michael TothDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.
Matthew PoynterDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.
Xuewei ZhuSection on Molecular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Kevin GibbsSection on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
D Clark FilesSection on Pulmonary, Critical Care, Allergy, and Immunologic Disease, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Funding

Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS-FLAME)R01HL143452 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FILES, DANIEL CLARK, POYNTER, MATTHEW E · 2018 to 2021
$3.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL143452
6 · The paper itself

Abstract

Skeletal muscle dysfunction in critical illnesses leaves survivors weak and functionally impaired. Macrophages infiltrate muscles; however, their functional role is unclear. We aim to examine muscle leukocyte composition and the effect of macrophages on muscle mass and function in the murine acute lung injury (ALI)-associated skeletal muscle wasting model. We performed flow cytometry of hindlimb muscle to identify myeloid cells pre-injury and time points up to 29 days after intratracheal lipopolysaccharide ALI. We evaluated muscle force and morphometrics after systemic and intramuscular clodronate-induced macrophage depletions between peak lung injury and recovery (day 5-6) versus vehicle control. Our results show muscle leukocytes changed over ALI course with day 3 neutrophil infiltration (130.5 ± 95.6cells/mg control to 236.3 ± 70.6cells/mg day 3) and increased day 10 monocyte abundance (5.0 ± 3.4%CD45

Indexed as

Acute Lung InjuryMacrophagesMice, Inbred C57BLMuscle, SkeletalAnimalsLipopolysaccharidesMaleMiceMuscular AtrophyLipopolysaccharidesacute lung injuryacute respiratory distress syndromeintensive care unit acquired weaknessmacrophageskeletal muscle wasting

Identifiers

PMID39327092
PMCPMC11427096

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.