Evidence map›Paper›PMID 39330289›Full record

ArticleMarine drugs2024

Sphaerococcenol A Derivatives: Design, Synthesis, and Cytotoxicity.

Dídia Sousa, Milene A G Fortunato, Joana Silva, Mónica Pingo, Alice Martins, Carlos A M Afonso, Rui Pedrosa, Filipa Siopa, Celso Alves

Abstract read
In one paragraph

Article in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Anti-Cancer Activity ofMarine drugs · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dídia SousaMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614 Peniche, Portugal.
Milene A G FortunatoResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.ORCID 0000-0003-1072-0709
Joana SilvaMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614 Peniche, Portugal.ORCID 0000-0003-1224-1699
Mónica PingoMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614 Peniche, Portugal.
Alice MartinsMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614 Peniche, Portugal.
Carlos A M AfonsoResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.ORCID 0000-0002-7284-5948
Rui PedrosaMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614 Peniche, Portugal.
Filipa SiopaResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.ORCID 0000-0002-4514-9154
Celso AlvesMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614 Peniche, Portugal.ORCID 0000-0003-1581-2127

Funding

European Union's Horizon 2020 No 951996Fundação para a Ciência e Tecnologia 2021.06598.BDFundação para a Ciência e Tecnologia 2022.09196.PTDCFundação para a Ciência e Tecnologia LA/P/0069/2020Fundação para a Ciência e Tecnologia Project Nº 022161Fundação para a Ciência e Tecnologia UIDB/04138/2020Fundação para a Ciência e Tecnologia UIDB/04292/2020Fundação para a Ciência e Tecnologia UIDP/04138/2020Fundação para a Ciência e Tecnologia UIDP/04292/2020Interreg Atlantic Area EAPA_0032/2022
6 · The paper itself

Abstract

Sphaerococcenol A is a cytotoxic bromoditerpene biosynthesized by the red alga

Indexed as

Antineoplastic AgentsA549 CellsApoptosisCell Line, TumorCell SurvivalDiterpenesDrug DesignHumansInhibitory Concentration 50MCF-7 CellsReactive Oxygen SpeciesRhodophytaStructure-Activity RelationshipAntineoplastic AgentsDiterpenesReactive Oxygen Speciesalgaeanticancerapoptosishemi-synthesismarine natural productsreactive oxygen species

Identifiers

PMID39330289
PMCPMC11432771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.