Evidence map›Paper›PMID 39330574›Full record

ArticleToxics2024

Multi-Walled Carbon Nanotubes Accelerate Leukaemia Development in a Mouse Model.

Qingqing Wang, Jingdan Han, Mujia Wei, Huikai Miao, Min Zhang, Biao Wu, Yao Chen, Yanwen Zheng, Robert Peter Gale, Bin Yin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Nanotoxicology: developments and new insights.Nanomedicine (London, England) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Qingqing WangClinical Medical Research Center, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Jingdan HanClinical Medical Research Center, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Mujia WeiClinical Medical Research Center, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi 214002, China.
Huikai MiaoDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China.
Min ZhangDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China.
Biao WuDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China.
Yao ChenDepartment of Laboratory Medicine, Jiangnan University Medical Center, Wuxi 214002, China.
Yanwen ZhengCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215123, China.
Robert Peter GaleHaematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK.
Bin YinClinical Medical Research Center, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi 214002, China.

Funding

National Key Scientific Project of China "973 Program", No. 2011CB933501the Natural Science Foundation of Jiangsu Province No. BK20181130the NSFC Project No. 81570132 and No. 81873437
6 · The paper itself

Abstract

Inflammation is associated with an increased risk of developing various cancers in both animals and humans, primarily solid tumors but also myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Multi-walled carbon nanotubes (MWCNTs), a type of carbon nanotubes (CNTs) increasingly used in medical research and other fields, are leading to a rising human exposure. Our study demonstrated that exposing mice to MWCNTs accelerated the progression of spontaneous MOL4070LTR virus-induced leukemia. Additionally, similar exposures elevated pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α and induced reactive oxygen species (ROS) in a murine macrophage cell line. These effects were significantly reduced in immunodeficient mice and when mice were treated with methoxypolyethylene glycol amine (PEG)-modified MWCNTs. These findings underscore the necessity of evaluating the safety of MWCNTs, particularly for those with hematologic cancers.

Indexed as

inflammationleukemiaMOL4070LTRmulti-walled carbon nanotubesPEG

Identifiers

PMID39330574
PMCPMC11435454

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.