Evidence map›Paper›PMID 39330776›Full record

ArticleVeterinary sciences2024

Effects of Exogenous Regulation of PPARγ on Ovine Oocyte Maturation and Embryonic Development In Vitro.

Hengbin Yu, Yue Zhang, Yidan Zhang, Shuaitong Chen, Zhenghang Li, Wenhui Pi, Weibin Zeng, Guangdong Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hengbin YuCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Yue ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Yidan ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Shuaitong ChenCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Zhenghang LiCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Wenhui PiCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Weibin ZengCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Guangdong HuCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0009-0003-8486-4227

Funding

National Natural Science Foundation of China 32060751Startup Fund for Scientific Research of High-level Talents of Shihezi University RCZK2021B34
6 · The paper itself

Abstract

Lactating oocytes consume a lot of energy during maturation, a large part of which comes from lipid metabolism. PPARγ is a key regulator of lipid metabolism. In this study, rosiglitazone (RSG), an activator of PPARγ, was added to a mature medium to investigate its effects on the levels of spindle and the chromosome arrangement, lipid deposition, reactive oxygen species (ROS), and glutathione (GSH) levels, oocyte secretion factors, apoptosis and lipid metabolism-related gene expression, and subsequent embryonic development during the maturation of sheep oocytes. The oocyte secretion factor affects gene expression related to apoptosis and lipid metabolism and subsequent embryonic development. The results showed that the proportion of spindle and normal chromosome arrangements increased in the 5 μM RSG treatment group, the lipid content increased after cell maturation, the ROS level decreased, and the GSH level increased. The expressions of oocyte secretion factor (

Indexed as

lipid metabolismoocyteoxidative stressPPARγsheep

Identifiers

PMID39330776
PMCPMC11435492

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.