Evidence map›Paper›PMID 39331346›Full record

ArticleBrain imaging and behavior2024

Association between large neutral amino acids and white matter hyperintensities in middle-aged adults at varying metabolic risk.

Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle A Gallagher, Barbara Strasser, Hirofumi Tanaka, Andreana P Haley

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Cherry YounDepartment of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX, 78712, USA. youncherry@gmail.com.
Marie L CaillaudDepartment of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX, 78712, USA.
Yanrong LiDepartment of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX, 78712, USA.
Isabelle A GallagherDepartment of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX, 78712, USA.
Barbara StrasserFaculty of Medicine, Sigmund Freud Private University Vienna, Vienna, Austria.
Hirofumi TanakaDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
Andreana P HaleyDepartment of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX, 78712, USA.

Funding

Neuroimaging Cognitive Vulnerability in HypertensionR01NS075565 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HALEY, ANDREANA PETROVA · 2011 to 2013
$986k
NIH HHS R01NS075565
6 · The paper itself

Abstract

This investigation delves into the interplay between large neutral amino acids (LNAA) and metabolic syndrome (MetS) in midlife adults, examining their collective influence on brain structure. While LNAA, such as tryptophan and phenylalanine, are known to bolster cognition in youth, these relationships often reverse later in life. Our study hypothesized an earlier reversal of these benefits in middle-aged adults with MetS, potentially signaling premature brain aging. Eighty participants between 40-61 years underwent MetS component quantification, LNAA measurement via high-performance liquid chromatography, and brain imaging to evaluate white matter hyperintensities (WMH) volume and medial temporal lobe (MTL) cortical thickness. Our linear regression analyses, adjusting for sex, age, and education, revealed that phenylalanine levels moderated the relationship between MetS and WMH volume (F(6, 69) = 3.134, p < 0.05, R

Indexed as

Magnetic Resonance ImagingMetabolic SyndromePhenylalanineWhite MatterAdultAmino Acids, NeutralBrainFemaleHumansMaleMiddle AgedTemporal LobeAmino Acids, NeutralPhenylalanineMetabolic SyndromeMidlife AdultsPhenylalanineWhite matter hyperintensities

Identifiers

PMID39331346

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.