ArticleProceedings of the National Academy of Sciences of the United States of America2024
Poly ADP-ribose signaling is dysregulated in Huntington disease.
Abstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- HDDF2-A Novel Patient-Derived Fibroblast Line from Huntington's Disease with Prominent Cellular Senescence and polyQ Pathology.Biomedicines · 2026Article
- STING-ERO1 signaling exacerbates PARylation-mediated parthanatos in sepsis.Cell communication and signaling : CCS · 2026Article
- Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and PARP1 hyperactive signaling.bioRxiv : the preprint server for biology · 2026Article
- Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic Frontiers.Apoptosis : an international journal on programmed cell death · 2026Review
- NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease.Essays in biochemistry · 2025Review
- Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases.Journal of Huntington's disease · 2025Review
- Disease-disease interactions: molecular links of neurodegenerative diseases with cancer, viral infections, and type 2 diabetes.Translational neurodegeneration · 2025Review
- Multiplexed stamp-transfer AFM deposition improves resolution of protein-DNA conformational states.Biophysical journal · 2025Article
- Analyzing different aging theories in the context of the brain: DNA damage, inflammation, redox imbalance, and neurodevelopment intertwine.Biogerontology · 2025Review
- Insights into RNA-mediated pathology in new mouse models of Huntington's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Parthanatos: Mechanisms, modulation, and therapeutic prospects in neurodegenerative disease and stroke.Biochemical pharmacology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Tamara MaiuriDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0002-6103-5835
Carlos Barba BazanDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0002-1884-5760
Rachel J HardingDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto ON M5S 3M2, Canada.ORCID 0000-0002-1134-391X
Nola BegejaDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0002-9805-8037
Tae-In KamNeurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-7241-4902
Lauren M ByrneUniversity College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.ORCID 0000-0003-1650-4273
Filipe B RodriguesUniversity College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.ORCID 0000-0002-5567-7938
Monica M WarnerDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0001-7951-9662
Kaitlyn NeumanDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0001-7699-9680
Muqtasid MansoorDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0001-8192-6590
Mohsen BadieeDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0003-3722-4609
Morgan DasovichDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0001-0000-7951-9662
Keona WangDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697.ORCID 0000-0002-7715-2489
Leslie M ThompsonDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697.ORCID 0000-0003-4573-9514
Anthony K L LeungDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0001-5569-4036
Sara N AndresDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0002-4795-2856
Edward J WildUniversity College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.ORCID 0000-0002-6921-7887
Ted M DawsonNeurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-6459-0893
Valina L DawsonNeurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-2915-3970
Cheryl H ArrowsmithStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.ORCID 0000-0002-4971-3250
Ray TruantDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.ORCID 0000-0003-2542-6641
Funding
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1MMolecular Mechanisms of Pathogenesis in Huntington’s diseaseR35NS116872 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Leslie Michels Thompson · 2020 to 2026
$8.5MParthanatos, AIF and PAAN-1 in Neuronal InjuryR37NS067525 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DAWSON, TED M., DAWSON, VALINA L. · 2015 to 2021
$5.3MRole of ADP-Ribosylation in Stress Granules-Equipment SupplementR01GM104135 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Anthony K L Leung · 2015 to 2026
$4.2MThe Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5MThe Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM149382 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI STEVEN E ROKITA · 2023 to 2026
$1.4MCanadian Government | Canadian Institutes of Health Research (CIHR) PJT-168966Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-180258CHDI Foundation (CHDI) CHDI002HHS | NIH (NIH) T32-CA009110HHS | NIH (NIH) T32GM080189Medical Research Council MR/M008592/1Medical Research Council MR/W026686/1NCI NIH HHS T32 CA009110NIGMS NIH HHS R01 GM104135NIGMS NIH HHS T32 GM080189NIGMS NIH HHS T32 GM149382NINDS NIH HHS R35 NS116872NINDS NIH HHS R37 NS067525UKRI | MRC | Medical Research Council Centre for Neurodevelopmental Disorders (CNDD) MR/M008592/1
Abstract
Huntington disease (HD) is a genetic neurodegenerative disease caused by cytosine, adenine, guanine (CAG) expansion in the
Indexed as
Huntingtin ProteinHuntington DiseasePoly Adenosine Diphosphate RiboseSignal TransductionDNA DamageDNA RepairFibroblastsHumansInduced Pluripotent Stem CellsNeuronsHTT protein, humanHuntingtin ProteinPoly Adenosine Diphosphate RibosehuntingtinHuntington’s diseasePARP1PARylationpoly ADP-ribose
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.