ArticleArchives of disease in childhood2024
Associations between maternal body mass index and childhood infections in UK primary care: findings from the Born in Bradford birth cohort study.
Article in Archives of disease in childhood, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Yonder: Obesity care, maternal body mass index and childhood infections, frozen shoulder and diabetes, and locums.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
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Abstract
objectiveTo explore associations between maternal body mass index (BMI) in early pregnancy and childhood infections.
designBirth cohort study linked to primary care records.
settingBradford, UK.
participantsLive singleton births within the Born in Bradford cohort study between 2007 and 2011. EXPOSURES: Maternal BMI in early pregnancy.
main outcome measuresThe total number of infections between birth and ~14 years of age with subgroup analysis by infection type and age.
resultsA total of 9037 mothers and 9540 children were included in the main analysis. 45% of women were of Pakistani ethnicity and 6417 women (56%) were overweight or obese. There was an overall trend for an increasing infection rate with increasing maternal BMI. In adjusted models, only those with obesity grade 2-3 had offspring with significantly higher rates of infection during the first year of life (RR 1.12 (95% CI 1.05 to 1.20)) compared with women of healthy weight. However, by age 5 to <15 years, children born to overweight women (RR 1.09 (95% CI 1.02 to 1.16)), obese grade 1 women (RR 1.18 (95% CI 1.09 to 1.28)) or obese grade 2 women (RR 1.31 (95% CI 1.16 to 1.48)) all had significantly higher rates of infection compared with those born to healthy weight mothers. Respiratory tract and skin/soft tissue infections made up the majority of excess infections.
conclusionsMaternal BMI was positively associated with rates of offspring infection in this study cohort, and suggests that we should be supporting women to achieve a healthy weight for pregnancy. Future research should investigate whether this is replicated in other populations, whether there is a causal association and the potential mechanisms and areas for intervention.
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