Evidence map›Paper›PMID 39333932›Full record

ArticleBMC nephrology2024

Low estimated glomerular filtration rate and proteinuria among adult diabetic patients in a tertiary hospital in Eastern Uganda - a cross-sectional study.

Moses Kirya, Denis Bwayo, Michael E Otim, Paul Bukhota Mutoo, John Peter Masete Masaba, Okibure Ambrose, Richard Katuramu

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Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Moses KiryaInternal Medicine at the Faculty of Health Sciences, Busitema University, Mbale, Uganda. kiryamoses8@gmail.com.
Denis BwayoFaculty of Health Sciences, Busitema University Mbale, Mbale, Uganda.
Michael E OtimCollege of Medicine, Dubai Medical University, Dubai, United Arab Emirates.
Paul Bukhota MutooInternal Medicine at the Faculty of Health Sciences, Busitema University, Mbale, Uganda.
John Peter Masete MasabaFaculty of Health Sciences, Busitema University Mbale, Mbale, Uganda.
Okibure AmbroseSchool of Public Health, Department of Epidemiology and Biostatistics, Makerere University, Kampala, Uganda.
Richard KaturamuInternal Medicine at the Faculty of Health Sciences, Busitema University, Mbale, Uganda.

Funding

Health Professions Education and training for strengthening the health system and services in UgandaR25TW011213 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KIGULI, SARAH · 2018 to 2022
$3.4M
FIC NIH HHS R25 TW011213Fogarty International Center of the National Institutes of Health, U.S. Department of State's Office of the U.S. Global AIDS Coordinator and Health Diplomacy (S/GAC), and President's Emergency Plan for AIDS Relief (PEPFAR) 1R25TW011213
6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is one of the most common complications of diabetes mellitus (DM). Diabetes mellitus contributes to about 66% of CKD cases globally. CKD results in increased morbidity and mortality and advanced stages often require kidney replacement therapy that is unaffordable for the majority of the patients. Developing countries have scanty data regarding CKD burden in diabetic patients.

objectivesThis study aimed at determining the prevalence of low estimated glomerular filtration rate (eGFR) and proteinuria and associated clinical and socio-demographic factors among adult diabetic patients attending the diabetic clinic of Mbale Regional Referral Hospital (MRRH).

methodsA cross-sectional study was conducted at the adult diabetic clinic of MRRH in Eastern Uganda. A total of 374 adult diabetic patients were enrolled. A urine sample for urine albumin creatinine ratio (UACR) determination and a venous blood sample for measurement of serum creatinine were obtained from each participant. The eGFR was determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and CKD was staged according to the Kidney Disease Improving Global Outcomes (KDIGO) classification.

resultsA total of 318 (85%) participants had an eGFR of ≤ 60 mL/min/1.73m2, UACR of ≥ 30g/g, or both. Only 6.1% were aware. Age, duration of DM, hypertension, and dyslipidemia were associated with low eGFR and proteinuria.

conclusionThere is a high prevalence of low eGFR and proteinuria among DM patients, 85% of the participants had these markers of CKD and the majority of them were undiagnosed. Over half of the DM patients had an eGFR consistent with advanced CKD. Strengthening routine screening for CKD biomarkers and equipping DM clinics with more diagnostic resources is recommended.

Indexed as

Glomerular Filtration RateProteinuriaRenal Insufficiency, ChronicTertiary Care CentersAdultAgedCross-Sectional StudiesDiabetes MellitusDiabetic NephropathiesFemaleHumansMaleMiddle AgedPrevalenceUgandaChronic kidney diseaseDiabetes mellitusGlomerular filtration rateProteinuria

Identifiers

PMID39333932
PMCPMC11428884

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.