ArticleLipids in health and disease2024
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and diabetic kidney disease in patients with diabetes in the United States: a cross-sectional study.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Nonlinear association of the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio with cognitive function in older Chinese adults: A prospective cohort study.The Journal of international medical research · 2026Article
- Association between non-HDL-cholesterol to HDL-cholesterol ratio (NHHR) and COPD: a cross-sectional study of 11,082 Chinese adults with predictive nomogram development.BMC pulmonary medicine · 2026Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and osteoporotic fracture.Frontiers in medicine · 2026Article
- Atherosclerosis index and diabetic foot ulcers: an NHANES database investigation.International journal of surgery (London, England) · 2025Article
- Relation of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio to residual risk in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF Project III cohort.Cardiovascular diabetology · 2025Observational
- Association of outcome with non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in hospitalized patients with congestive heart failure: a retrospective analysis.Journal of cardiothoracic surgery · 2025Article
- U-shaped relationship between the non-HDL to HDL cholesterol ratio and mortality in hypertensive individuals in the study from NHANES database.Scientific reports · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cerebral atherosclerotic stenosis: a retrospective study.Lipids in health and disease · 2025Article
- Article
- Association of non-highdensity lipoprotein cholesterol to highdensity lipoprotein cholesterol ratio (NHHR) and subsequent hypertension and heart diseases: findings from the CHARLS cohort.Aging clinical and experimental research · 2025Article
- Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018.Frontiers in endocrinology · 2025Article
- Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults.Frontiers in nutrition · 2025Article
- Association between life's crucial 9 and kidney stones: a population-based study.Frontiers in medicine · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hyperuricemia: evidence from the CHARLS study.Frontiers in nutrition · 2025Article
- Surrogate endpoints in diabetic kidney disease: current perspectives and future directions.Frontiers in endocrinology · 2025Review
- Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001-2018.Frontiers in nutrition · 2025Article
- Predictive value of serum uric acid-to-albumin ratio for diabetic kidney disease in patients with type 2 diabetes mellitus: a case-control study.Frontiers in endocrinology · 2025Article
- Association Between GGT/HDL-C Ratio and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThis paper investigated the link between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and diabetic kidney disease (DKD) in adult diabetic patients and identified the optimal NHHR value for impacting DKD.
methodsThis cross-sectional research made use of records from the National Health and Nutrition Examination Survey (NHANES) executed between 2005 and 2016. The link of NHHR to DKD risk was analyzed by logistic regression and restricted cubic spline (RCS) models. The stability and reliability of the results were assessed by subgroup analysis and sensitivity analysis.
resultsIn total, 4,177 participants were involved. As a continuous variable, NHHR was markedly connected to an increased risk of DKD (OR 1.07, 95% CI 1.02, 1.12, P < 0.01). When NHHR was grouped in quartiles, relative to the reference set, the highest NHHR group was also linked to a heightened risk of DKD (OR 1.23, 95% CI 1.01, 1.50, P < 0.05). The outcome of RCS show a "J" shaped correlation between NHHR and DKD risk (P for nonlinear = 0.0136). The risk of developing DKD was the lowest when NHHR equals 2.66. Subgroup analysis revealed that the link of NHHR to DKD persisted in participants aged below 40, females, non-smokers, and those without hyperuricemia. Sensitivity analysis demonstrated a certain robustness in this association.
conclusionA meaningful link is present between NHHR and DKD. An NHHR value of around 2.66 could represent the ideal cutoff for assessing DKD risk.
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