ArticleBMC public health2024
Association between tooth loss and depression mediated by lifestyle and Inflammation- a cross-sectional investigation.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Tooth loss elevates all-cause and cause-specific mortality in adults with chronic kidney disease: The mediating role of frailty.Medicine · 2026Article
- Chewing function, diet quality, and risk of metabolic syndrome and mortality: analysis of NHANES 1999-2018.BMC oral health · 2026Article
- Unraveling links between lifestyle behaviors and depressive symptoms: a network analysis using NHANES 2007-2018 data.Annals of general psychiatry · 2026Article
- The Effect of Tooth Loss on Depression and Anxiety Among Older Adults in China: The Mediating Role of Dietary Diversity.Nutrients · 2026Article
- EXO-VNN2 derived from 3D-cultured DPSCs enhances the inflammatory response of PDLSCs and suppresses bone regeneration in periodontitis.Stem cell research & therapy · 2026Article
- Association of Chewing Difficulty and Number of Remaining Teeth with Anxiety (GAD-7) Among Korean Adults: Evidence from the 2023 KNHANES.Healthcare (Basel, Switzerland) · 2025Article
- Association between tooth loss and geriatric syndromes in older adults: a cohort study from a rural area in eastern China.Aging clinical and experimental research · 2025Article
- The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study.Frontiers in psychiatry · 2024Article
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Authors and funding
7 authors.
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Abstract
backgroundDepression and tooth loss are associated with the occurrence of systemic disease or the progression of multi-factorial disease, and both are considered important public health issues by World Health Organization (WHO). Previous research just suggested that tooth loss can generate psychological stress, low self-esteem, anxiety and other emotional disturbances. However, the precise correlation and underlying mechanisms between depression and tooth loss remains poorly understood. Consequently, we aim to explore the association between depression and tooth loss through a cross-sectional study, as well as investigate potential pathways of influence.
methodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES). Logistic regression models were employed to examine the relationship between depression and tooth loss, as well as the associations among healthy lifestyle, systemic immune-inflammation index (SII), depression and tooth loss. Through the mediating effect analysis by bootstrapping analysis, we evaluated the mediating effects of healthy lifestyle and SII between depression and tooth loss.
resultsDepressed patients were more likely to be toothless, and at the same time showed a tendency to have more missing teeth, with odds ratio (OR) = 1.305 (1.098, 1.551), p = 0.003 for 1-7 missing teeth, OR = 1.557 (1.166, 2.079), p = 0.003 for 8-14 missing teeth, and OR = 1.960 (1.476, 2.603), p<0.001 for 15-28 missing teeth. Lower healthy lifestyle scores and higher SII were both associated with more tooth loss. Healthy lifestyle and SII played a partial mediating role in this relationship, with a mediating effect ratio of 41.691% and 3.289%, respectively.
conclusionsDepression was positively associated with more severe tooth loss, which was partly mediated by lifestyle and SII. Therefore, attention should also be paid to the effects of depression as a mental disorder on physical health, such as depression and tooth loss. Adopting a healthier lifestyle and controlling systemic inflammation may be potential ways to reduce the impact of depression and tooth loss.
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