Evidence map›Paper›PMID 39334304›Full record

ArticleBiomarker research2024

Oncogenic ACSM6 impairs CD8

Zhenyu Nie, Bolong Liu, Jinhui Liu, Xiongbing Zu, Juanhua Wang, Jinbo Chen, Benyi Fan, Dingshan Deng

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarker research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenyu Nie *Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
Bolong Liu *Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
Jinhui LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, China.
Xiongbing ZuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, China.
Juanhua WangHunan Vocational and Technical College of Environmental Biology, Changsha, China.
Jinbo ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, China. chenjinbo@csu.edu.cn.
Benyi FanDepartment of Urology, Xiangya Hospital, Central South University, Changsha, China. fanbenyi2009@yeah.net.
Dingshan DengDepartment of Urology, Xiangya Hospital, Central South University, Changsha, China. dds15116217256@163.com.

Funding

China Postdoctoral Science Foundation 2024M753688Hunan Provincial Key Area Research Plan 2023SK2016Hunan Provincial Natural Science Foundation Science and Health Project 2022JJ70120Hunan Provincial Science Foundation 2019JJ40269National Nature Science Foundation of China 82303760Postdoctoral Fellowship Program of CPSF GZC20233176
6 · The paper itself

Abstract

Resistance to immunotherapy in bladder cancer has greatly limited its clinical application. Through single-cell sequencing, we determined that ACSM6, an oncogene that is highly expressed in bladder cancer, promotes the abilities of proliferation, cloning, migration, and invasion. The key point is that ACSM6 can also lead to a non-inflammatory immune microenvironment by inhibiting the chemotaxis and tumor killing ability of CD8

Indexed as

ACSM6Bladder cancerImmunotherapy resistanceNon-inflammatory immune microenvironmentTumor microenvironment

Identifiers

PMID39334304
PMCPMC11437728

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.