Evidence map›Paper›PMID 39334596›Full record

ArticleChildren (Basel, Switzerland)2024

Genome-Wide Mapping of Consanguineous Families Confirms Previously Implicated Gene Loci and Suggests New Loci in Specific Language Impairment (SLI).

Adnan Yousaf, Huma Hafeez, Muhammad Asim Raza Basra, Mabel L Rice, Muhammad Hashim Raza, Muhammad Imran Shabbir

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adnan YousafDepartment of Biological Sciences, International Islamic University, Islamabad 45500, Pakistan.
Huma HafeezCentre for Clinical and Nutritional Chemistry, School of Chemistry, University of the Punjab, New Campus Lahore, Lahore 54590, Pakistan.
Muhammad Asim Raza BasraCentre for Clinical and Nutritional Chemistry, School of Chemistry, University of the Punjab, New Campus Lahore, Lahore 54590, Pakistan.
Mabel L RiceSpeech-Language-Hearing: Sciences & Disorders, University of Kansas, Lawrence, KS 66045-7555, USA.
Muhammad Hashim RazaSpeech-Language-Hearing: Sciences & Disorders, University of Kansas, Lawrence, KS 66045-7555, USA.ORCID 0000-0002-7027-5195
Muhammad Imran ShabbirDepartment of Biological Sciences, International Islamic University, Islamabad 45500, Pakistan.

Funding

Genetic studies of specific language impairment (SLI) using consanguineousfamiliesR21DC017830 · NIDCD · UNIVERSITY OF KANSAS LAWRENCE · PI RAZA, MUHAMMAD HASHIM · 2020 to 2022
$440k
NIDCD NIH HHS R21 DC017830NIH HHS 1R21DC017830-03A1
6 · The paper itself

Abstract

Specific language impairment (SLI) is a developmental disorder with substantial genetic contributions. A genome-wide linkage analysis and homozygosity mapping were performed in five consanguineous families from Pakistan. The highest LOD scores of 2.49 at 12p11.22-q11.21 in family PKSLI-31 and 1.92 at 6p in family PKSLI-20 were observed. Homozygosity mapping showed a loss of heterozygosity on 1q25.3-q32.2 and 2q36.3-q37.3 in PKSLI-20. A loss of heterozygosity mapped, in PKSLI-31 and PKSLI-34 flanks,

Indexed as

genome-widehomozygosity mappinglociparametric linkage analysisspecific language impairment

Identifiers

PMID39334596
PMCPMC11429814

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.