ReviewChildren (Basel, Switzerland)2024
Proposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review.
Review in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Understanding how adverse childhood experiences influence the development of postpartum post-traumatic stress disorder: a qualitative study in China.European journal of psychotraumatology · 2026Article
- Strengths-based resilience: the biopsychosocial factors that differentiate 12-year mental well-being trajectories following adverse childhood experiences.Psychological medicine · 2026Article
- Associations between maternal adverse childhood experiences and children's physical health conditions: A longitudinal study.Public health in practice (Oxford, England) · 2026Article
- Adverse Childhood Experiences and Disease Activity Are Associated with Post-Traumatic Stress Symptoms in Crohn's Disease.Advances in therapy · 2026Article
- Unseen wounds of childhood: Emotional abuse, neglect, and later diabetes vulnerability in Saudi Arabia: A Cross-sectional study.Medicine · 2026Article
- Are Maternal Adverse Childhood Experiences Associated with Their Preschool Children's Sleep Disruptions? Longitudinal Mediation Through Mothers' Depressive Symptoms and Children's Screen Time.Children (Basel, Switzerland) · 2026Article
- Adverse childhood experiences and late-life depression in older Chinese adults: the mediating roles of sleep disorders and chronic diseases.BMC geriatrics · 2025Article
- Are Children's Externalizing and Internalizing Behaviours at 5 Years Predicted by Maternal Perinatal Depression Trajectory Profiles?Children (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse childhood experiences (ACEs; e.g., physical abuse) can impact lifelong mental health both directly and intergenerationally, with effects transmitted from the parent to the child. Several physiological mechanisms have been proposed to explain the impacts of ACEs on mental health. The purpose of this narrative review was to synthesize and critique the peer-reviewed literature on physiological mechanisms proposed to underlie the impacts of ACEs on mental health, specifically: (1) hypothalamic-pituitary-adrenal axis functioning, (2) inflammation, (3) genetic inheritance and differential susceptibility, (4) epigenetics, (5) brain structure and function, (6) oxidative stress, and (7) metabolic profiles. We searched Google Scholar using variations of the terms "adverse childhood experiences", "mechanisms", and "mental health" to locate relevant peer-reviewed literature. We also mined citations of the identified literature to find additional important sources. The role of inflammation in the etiology of mental health conditions among those exposed to ACEs appeared promising, followed by hypothalamic-pituitary-adrenal axis functioning, brain structure and function, genetics, epigenetics, metabolism, and lastly, oxidative stress. Replication studies that examine the associations among ACEs, genetic inheritance and differential susceptibility, epigenetics, oxidative stress, and metabolism are required to better define links with mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.