Evidence mapPaperPMID 39334701Full record

ArticleAntioxidants (Basel, Switzerland)2024

Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV.

Harpreet Kaur, Ravi K Alluri, Kunling Wu, Robert C Kalayjian, William S Bush, Frank J Palella, Susan L Koletar, Corrilynn O Hileman, Kristine M Erlandson, Ronald J Ellis and 5 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Harpreet KaurDepartment of Genomic Medicine, Cleveland Clinic/Lerner Research Institute, Cleveland, OH 44195, USA.
Ravi K AlluriDepartment of Genomic Medicine, Cleveland Clinic/Lerner Research Institute, Cleveland, OH 44195, USA.
Kunling WuHarvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Robert C KalayjianDepartment of Medicine/Infectious Diseases, MetroHealth Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
William S BushDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-9729-6519
Frank J PalellaDepartment of Medicine/Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Susan L KoletarDepartment of Medicine/Infectious Diseases, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1370-7438
Corrilynn O HilemanDepartment of Medicine/Infectious Diseases, MetroHealth Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Kristine M ErlandsonDepartment of Medicine/Infectious Diseases, University of Colorado-Anschutz Medical Campus, Aurora, CO 80045, USA.
Ronald J EllisDepartment of Neurosciences, University of California-San Diego, San Diego, CA 92103, USA.ORCID 0000-0003-4931-752X
Roger J BedimoMedicine/Infectious Diseases Section, VA North Texas Health Care System, Dallas, TX 75216, USA.
Babafemi O TaiwoDepartment of Medicine/Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Katherine K TassiopoulosHarvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Asha R KallianpurDepartment of Genomic Medicine, Cleveland Clinic/Lerner Research Institute, Cleveland, OH 44195, USA.ORCID 0000-0002-6483-523X
ACTG A5322 Study Team

Funding

AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related InfectionsUM1AI068636 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 to 2025
$229.0M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2021 to 2025
$81.6M
Pitt-Ohio State Clinical Trials UnitUM1AI069494 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 to 2025
$13.1M
UNC Center for AIDS Research Core F BiostatisticsP30AI050410 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2001 to 2025
$10.9M
National Institute of Health 5R03 MH123291; 5R01 MH124530NIAID NIH HHS P30 AI050410NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069494
6 · The paper itself

Abstract

Ferroptosis is implicated in viral neuropathogenesis and may underlie HIV-associated neurocognitive impairment (NCI). Emerging data also suggest differences in brain iron transport by sex. We hypothesized that circulating ferritins that inhibit ferroptosis associate with neurocognitive function and NCI in people with HIV (PWH) in a sex-biased manner. Serum ferritin heavy-chain-1 (FTH1), ferritin light-chain (FTL), and urinary F

Indexed as

ferritin heavy chainferritin light chainferroptosisHIVironlipid peroxidationneurocognitive domainsneurocognitive impairmentoxidative stress

Identifiers

PMID39334701
PMCPMC11429126

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.