Evidence mapPaperPMID 39334798Full record

ArticleAntioxidants (Basel, Switzerland)2024

LDL-c/HDL-c Ratio and NADPH-Oxidase-2-Derived Oxidative Stress as Main Determinants of Microvascular Endothelial Function in Morbidly Obese Subjects.

Jorge Santos, José M La Fuente, Argentina Fernández, Paula Ruano, Javier Angulo

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jorge SantosUnidade de Cirurgia Esofagogástrica e Tratamento Cirúrgico de Obesidade, Centro Hospitalar e Universitário de Santo António (CHUdSA), 4099-001 Porto, Portugal.
José M La FuenteServiço de Urologia, Centro Hospitalar e Universitário de Santo António (CHUdSA), 4099-001 Porto, Portugal.
Argentina FernándezServicio de Histología-Investigación. Unidad de Investigación Traslacional en Cardiología-IRYCIS/UFV, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Paula RuanoServicio de Histología-Investigación. Unidad de Investigación Traslacional en Cardiología-IRYCIS/UFV, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Javier AnguloServicio de Histología-Investigación. Unidad de Investigación Traslacional en Cardiología-IRYCIS/UFV, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.ORCID 0000-0002-3789-9465

Funding

Instituto de Salud Carlos III PI15/01160
6 · The paper itself

Abstract

The identification of obese subjects at higher risk for cardiovascular disease (CVD) is required. We aimed to characterize determinants of endothelial dysfunction, the initial step to CVD, in small omental arteries of visceral fat from obese subjects. The influences of analytical parameters and vascular oxidative stress mediated by NADPH-oxidase-2 (NOX2) on endothelial function were determined. Specimens were obtained from 51 obese subjects undergoing bariatric surgery and 14 non-obese subjects undergoing abdominal surgery. Obese subjects displayed reduced endothelial vasodilation to bradykinin (BK). Endothelial vasodilation (pEC

Indexed as

endothelial dysfunctionhigh-density lipoprotein cholesterolhuman mesenteric small arterieshuman obesitylow-density lipoprotein cholesterolNADPH-oxidase

Identifiers

PMID39334798
PMCPMC11444145

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.