Evidence map›Paper›PMID 39334807›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Synthesis, Characterization and Assessment of Antioxidant and Melanogenic Inhibitory Properties of Edaravone Derivatives.

R Divya Mohan, S A Anaswara, Naveen V Kulkarni, Dimitar G Bojilov, Stanimir P Manolov, Iliyan I Ivanov, Jamelah S Al-Otaibi, Y Sheena Mary

Abstract read
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In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Evaluation of antioxidant and anti-inflammatory potential andJournal of enzyme inhibition and medicinal chemistry · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

R Divya MohanDepartment of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri 690525, India.
S A AnaswaraDepartment of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri 690525, India.
Naveen V KulkarniDepartment of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri 690525, India.ORCID 0000-0003-4566-9384
Dimitar G BojilovDepartment of Organic Chemistry, University of Plovdiv, 24 Tzar Assen str., 4000 Plovdiv, Bulgaria.ORCID 0000-0001-6569-8348
Stanimir P ManolovDepartment of Organic Chemistry, University of Plovdiv, 24 Tzar Assen str., 4000 Plovdiv, Bulgaria.ORCID 0000-0002-0314-6553
Iliyan I IvanovDepartment of Organic Chemistry, University of Plovdiv, 24 Tzar Assen str., 4000 Plovdiv, Bulgaria.ORCID 0000-0002-4662-3735
Jamelah S Al-OtaibiDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Y Sheena MaryDepartment of Physics, FMNC, University of Kerala, Kollam 691001, India.

Funding

Amrita Vishwa Vidyapeetham 0000Plovdiv University 0000Princess Nourah bint Abdulrahman University 0000
6 · The paper itself

Abstract

A series of edaravone derivatives and the corresponding Cu(II) complexes were synthesized and characterized using spectroscopic and analytical techniques such as IR, UV, NMR and elemental analysis. Antioxidant activities of all compounds were examined using free radical scavenging methods such as hydrogen peroxide scavenging activity (HPSA), 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) assays. All of the tested compounds exhibited good antioxidant activity. Further, the frontier orbital energy levels, as well as various chemical properties, were determined using the density functional theory (DFT) calculations. The MEP maps of all of the derivatives were plotted to identify the nucleophilic and electrophilic reactive sites. Further, binding energies of all of the organic compounds with the protein tyrosinase was investigated to determine their potential anti-melanogenic applications. The selected ligand,

Indexed as

antioxidant activitycopper(II) complexesedaravone derivativesmelanogenic inhibition activitymolecular dockingmolecular dynamics simulationtyrosinase-binding

Identifiers

PMID39334807
PMCPMC11429142

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.