Evidence map›Paper›PMID 39334820›Full record

ArticleBiomolecules2024

BMP2 Diminishes Angiotensin II-Induced Atrial Fibrillation by Inhibiting NLRP3 Inflammasome Signaling in Atrial Fibroblasts.

Yue Yuan, Hang Zhang, Erwen Xia, Xinbo Zhao, Qiang Gao, Hongyuan Mu, Xingzuo Liu, Yuanye Tian, Lei Liu, Qiuling Shen and 1 more

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Gene Therapies in Atrial Fibrillation.Journal of cardiovascular translational research · 2025
    Review
  4. Animal and cellular models of atrial fibrillation: a review.Frontiers in cardiovascular medicine · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue YuanDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.ORCID 0000-0003-3980-0630
Hang ZhangDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Erwen XiaDepartment of General Medicine, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Xinbo ZhaoDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Qiang GaoDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Hongyuan MuDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Xingzuo LiuDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Yuanye TianDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Lei LiuDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Qiuling ShenDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Li ShengDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.

Funding

First Affiliated Hospital of Harbin Medical University No. 2022IIT206National Natural Science Foundation of China No.82370336, No.81900302 and No.81300133
6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia to affect 1% of the global population and increases with age. Atrial fibrosis is a crucial substrate for promoting structural remodeling to cause atrial arrhythmogenesis. Bone morphogenic protein 2 (BMP2) has been reported to be involved in cardiac fibrogenesis. However, its role in modulating atrial fibrosis to affect AF development remains unknown. Our study aimed to investigate the expression of BMP2 under different AF conditions and the effect of BMP2 on the progression of atrial fibrosis using an angiotensin II (Ang II) rat model and an ex vivo cardiac fibroblast model. The qRT-PCR and Western blot assay showed increased

Indexed as

Angiotensin IIAtrial FibrillationBone Morphogenetic Protein 2FibroblastsHeart AtriaInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinSignal TransductionAnimalsDisease Models, AnimalFibrosisHumansMaleRabbitsRatsRats, Sprague-DawleyAngiotensin IIBMP2 protein, humanBmp2 protein, ratBone Morphogenetic Protein 2InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratatrial fibrillationatrial fibrosisbone morphogenic protein 2inflammasome signaling

Identifiers

PMID39334820
PMCPMC11430365

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.