Evidence mapPaperPMID 39334836Full record

ArticleBiomolecules2024

Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI.

Martin S Lietzén, Andrea Mari, Ronja Ojala, Jaakko Hentilä, Kalle Koskensalo, Riikka Lautamäki, Eliisa Löyttyniemi, Riitta Parkkola, Virva Saunavaara, Anna K Kirjavainen and 7 more

Abstract readTwin Study
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Martin S LietzénTurku PET Centre, University of Turku, 20521 Turku, Finland.
Andrea MariInstitute of Neuroscience, National Research Council (CNR), 35128 Padua, Italy.
Ronja OjalaTurku PET Centre, University of Turku, 20521 Turku, Finland.ORCID 0000-0002-2393-0281
Jaakko HentiläTurku PET Centre, University of Turku, 20521 Turku, Finland.
Kalle KoskensaloDepartment of Medical Physics, Turku University Hospital, 20520 Turku, Finland.ORCID 0000-0001-8026-1099
Riikka LautamäkiHeart Centre, Turku University Hospital, 20520 Turku, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku, 20520 Turku, Finland.
Riitta ParkkolaDepartment of Radiology, Turku University Hospital and University of Turku, 20520 Turku, Finland.
Virva SaunavaaraTurku PET Centre, University of Turku, 20521 Turku, Finland.
Anna K KirjavainenTurku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, 20521 Turku, Finland.ORCID 0000-0003-3981-2973
Johan RajanderTurku PET Centre, Accelerator Laboratory, Åbo Akademi University, 20500 Turku, Finland.ORCID 0000-0003-3591-0963
Tarja MalmA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Leo LahtiDepartment of Computing, University of Turku, 20521 Turku, Finland.ORCID 0000-0001-5537-637X
Juha O RinneTurku PET Centre, University of Turku, 20521 Turku, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-8522-1288
Patricia IozzoInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Jarna C HannukainenTurku PET Centre, University of Turku, 20521 Turku, Finland.ORCID 0000-0002-8692-4049

Funding

Emil Aaltonen foundationFinnish Cultural FoundationMaija and Matti Vaskio Foundationthe Finnish Diabetes Research Foundation
6 · The paper itself

Abstract

Obesity and sedentarism are associated with increased liver and pancreatic fat content (LFC and PFC, respectively) as well as impaired organ metabolism. Exercise training is known to decrease organ ectopic fat but its effects on organ metabolism are unclear. Genetic background affects susceptibility to obesity and the response to training. We studied the effects of regular exercise training on LFC, PFC, and metabolism in monozygotic twin pairs discordant for BMI. We recruited 12 BMI-discordant monozygotic twin pairs (age 40.4, SD 4.5 years; BMI 32.9, SD 7.6, 8 female pairs). Ten pairs completed six months of training intervention. We measured hepatic insulin-stimulated glucose uptake using [

Indexed as

Body Mass IndexExerciseGlucoseLipid MetabolismLiverObesityPancreasPositron-Emission TomographyAdultFemaleHumansMaleMiddle AgedTwins, MonozygoticGlucoseectopic fatglucose uptakeinsulin sensitivitylow-grade inflammationpancreas

Identifiers

PMID39334836
PMCPMC11430379

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.