Evidence map›Paper›PMID 39334909›Full record

ArticleBiomolecules2024

Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation.

Valeria Lallai, TuKiet T Lam, Rolando Garcia-Milian, Yen-Chu Chen, James P Fowler, Letizia Manca, Daniele Piomelli, Kenneth Williams, Angus C Nairn, Christie D Fowler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valeria LallaiDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-5674-8988
TuKiet T LamYale/NIDA Neuroproteomics Center, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-4850-3462
Rolando Garcia-MilianYale/NIDA Neuroproteomics Center, Yale University, New Haven, CT 06511, USA.ORCID 0000-0003-1557-566X
Yen-Chu ChenDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.
James P FowlerDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.
Letizia MancaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-4550-618X
Daniele PiomelliDepartment and Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.
Kenneth WilliamsYale/NIDA Neuroproteomics Center, Yale University, New Haven, CT 06511, USA.ORCID 0000-0001-7792-9588
Angus C NairnYale/NIDA Neuroproteomics Center, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-7075-0195
Christie D FowlerDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-2864-2163

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1M
Impact of THC on Extracellular Vesicle SignalingR01DA051831 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FOWLER, CHRISTIE D · 2020 to 2024
$2.0M
High Resolution Tandem Mass Spectrometer to Meet Growing Demand for Proteomics at YaleS10OD023651 · OD · YALE UNIVERSITY · PI LAM, TUKIET T · 2018 to 2018
$572k
NIDA NIH HHS P30 DA018343NIDA NIH HHS R01 DA051831NIH HHS S10 OD023651NIH NIDA DA018343NIH NIDA R01DA051831NIH SIG OD023651
6 · The paper itself

Abstract

Given the increasing use of cannabis in the US, there is an urgent need to better understand the drug's effects on central signaling mechanisms. Extracellular vesicles (EVs) have been identified as intercellular signaling mediators that contain a variety of cargo, including proteins. Here, we examined whether the main psychoactive component in cannabis, Δ9-tetrahydrocannabinol (THC), alters EV protein signaling dynamics in the brain. We first conducted

Indexed as

BrainDronabinolExtracellular VesiclesProteomicsAdministration, InhalationAnimalsFemaleMaleRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Signal TransductionDronabinolReceptor, Cannabinoid, CB1cannabiscerebrospinal fluidextracellular vesiclesproteomicTHC

Identifiers

PMID39334909
PMCPMC11430348

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.