Evidence map›Paper›PMID 39334914›Full record

ArticleBiomolecules2024

The Effects of Kynurenic Acid in Zebrafish Embryos and Adult Rainbow Trout.

Marta Marszalek-Grabska, Monika Turska-Kozlowska, Edyta Kaczorek-Lukowska, Katarzyna Wicha-Komsta, Waldemar A Turski, Andrzej K Siwicki, Kinga Gawel

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In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marta Marszalek-GrabskaDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8B Str., 20-090 Lublin, Poland.ORCID 0000-0002-2487-9131
Monika Turska-KozlowskaDepartment of Molecular Biology, The John Paul II Catholic University of Lublin, Konstantynow 1H, 20-708 Lublin, Poland.ORCID 0000-0002-2400-591X
Edyta Kaczorek-LukowskaDepartment of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13 Str., 10-719 Olsztyn, Poland.ORCID 0000-0002-9962-0917
Katarzyna Wicha-KomstaDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8B Str., 20-090 Lublin, Poland.ORCID 0000-0001-9945-7446
Waldemar A TurskiDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8B Str., 20-090 Lublin, Poland.ORCID 0000-0002-5805-5106
Andrzej K SiwickiDepartment of Ichiopathology and Fish Health Prevention, National Inland Fisheries Institute in Olsztyn, Oczapowskiego 10 Str., 10-917 Olsztyn, Poland.
Kinga GawelDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8B Str., 20-090 Lublin, Poland.ORCID 0000-0001-8857-847X

Funding

Medical University of Lublin ds 448 and ds 449National Science Centre NN 308578540
6 · The paper itself

Abstract

Kynurenic acid (KYNA) is a metabolite of tryptophan formed on the kynurenine pathway. Its pharmacological effects are relatively well characterized in mammals, whereas its role in fish is poorly understood. Therefore, the aim of the study was to expand the knowledge of KYNA's presence inside a fish's body and its impact on fish development and function. The study was performed on zebrafish larvae and adult rainbow trout. We provide evidence that KYNA is present in the embryo, larva and mature fish and that its distribution in organs varies considerably. A study of KYNA's effect on early larval development suggests that it can accelerate larval maturation, especially under conditions that are suboptimal for fish growth. Moreover, KYNA in concentrations over 1 mM caused morphological impairment and death of larvae. However, long-lasting exposure of larvae to subtoxic concentrations of KYNA does not affect the behavior of 5-day-old larvae kept under standard optimal conditions. We also show that ingestion of KYNA-supplemented feed can lead to KYNA accumulation, particularly in the pyloric caeca of mature trout. These results shed new light on the relevance of KYNA and provide new impulse for further research on the importance of the kynurenine pathway in fish.

Indexed as

Embryo, NonmammalianKynurenic AcidLarvaOncorhynchus mykissZebrafishAnimalsKynurenic Acidkynurenic acidrainbow troutzebrafish embryozebrafish larvae

Identifiers

PMID39334914
PMCPMC11429597

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.