Evidence map›Paper›PMID 39335447›Full record

ArticleBiomedicines2024

Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.

Ronald A M Buijsen, Linda M van der Graaf, Elsa C Kuijper, Barry A Pepers, Elena Daoutsali, Lotte Weel, Vered Raz, David A Parfitt, Willeke M C van Roon-Mom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ronald A M BuijsenDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-9722-8110
Linda M van der GraafDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Elsa C KuijperDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-0243-7826
Barry A PepersDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Elena DaoutsaliDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Lotte WeelDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Vered RazDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-3152-1952
David A ParfittDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Willeke M C van Roon-MomDepartment of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Funding

Hersenstichting DR-2018-00253Netherlands Organisation for Health Research and Development PTO2 project 446002002
6 · The paper itself

Abstract

Antisense technology demonstrates significant potential for addressing inherited brain diseases, with over a dozen products already available and numerous others in the development pipeline. The versatility of differentiating induced pluripotent stem cells (iPSCs) into nearly all neural cell types proves invaluable for comprehending the mechanisms behind neurological diseases, replicating cellular phenotypes, and advancing the testing and development of new therapies, including antisense oligonucleotide therapeutics. While delivering antisense oligonucleotides (ASOs) to human iPSC-based neuronal models has posed challenges, this study explores various delivery methods, including lipid-based transfection, gymnotic uptake, Ca

Indexed as

ASO deliveryCEMorganoids

Identifiers

PMID39335447
PMCPMC11428300

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.