Evidence map›Paper›PMID 39335866›Full record

ReviewFoods (Basel, Switzerland)2024

A Comprehensive Overview of Postbiotics with a Special Focus on Discovery Techniques and Clinical Applications.

Anand Kumar, Katelyn M Green, Manmeet Rawat

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07278024 (To Investigate the Effect of Postbiotic Intervention on Vaginal Microbiota in Infertile Women), which is not on this map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07278024 nacompletednot on this mapstarted 2025, after this paper: background citation

To Investigate the Effect of Postbiotic Intervention on Vaginal Microbiota in Infertile Women

TypeinterventionalSponsorKaohsiung Veterans General Hospital.Ran2025 to 2025Enrolled15ConditionsInfertile Women Undergoing IVF or ICSIArmspostbiotics
3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anand KumarBiochemistry and Biotechnology Group, Los Alamos National Laboratory, Bioscience Division, Los Alamos, NM 87545, USA.ORCID 0000-0001-9290-0927
Katelyn M GreenBiochemistry and Biotechnology Group, Los Alamos National Laboratory, Bioscience Division, Los Alamos, NM 87545, USA.
Manmeet RawatDepartment of Medicine, The Penn State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-8325-3390

Funding

Los Alamos National Laboratory the Laboratory Directed Research and Development grants 20210612ECR and 20240092DR
6 · The paper itself

Abstract

The increasing interest in postbiotics, a term gaining recognition alongside probiotics and prebiotics, aligns with a growing number of clinical trials demonstrating positive outcomes for specific conditions. Postbiotics present several advantages, including safety, extended shelf life, ease of administration, absence of risk, and patentability, making them more appealing than probiotics alone. This review covers various aspects, starting with an introduction, terminology, classification of postbiotics, and brief mechanisms of action. It emphasizes microbial metabolomics as the initial step in discovering novel postbiotics. Commonly employed techniques such as NMR, GC-MS, and LC-MS are briefly outlined, along with their application principles and limitations in microbial metabolomics. The review also examines existing research where these techniques were used to identify, isolate, and characterize postbiotics derived from different microbial sources. The discovery section concludes by highlighting challenges and future directions to enhance postbiotic discovery. In the second half of the review, we delve deeper into numerous published postbiotic clinical trials to date. We provide brief overviews of system-specific trial applications, their objectives, the postbiotics tested, and their outcomes. The review concludes by highlighting ongoing applications of postbiotics in extended clinical trials, offering a comprehensive overview of the current landscape in this evolving field.

Indexed as

approacheschallengesclinical applicationdiscoverymicrobial metabolomicsongoing trialspostbiotics

Identifiers

PMID39335866
PMCPMC11431132

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.