Evidence mapPaperPMID 39337249Full record

ArticleInternational journal of molecular sciences2024

CD26 Is Differentially Expressed throughout the Life Cycle of Infantile Hemangiomas and Characterizes the Proliferative Phase.

Bruno Lorusso, Antonella Nogara, Rodanthi Fioretzaki, Emilia Corradini, Roberta Bove, Giovanni Roti, Andrea Gherli, Anna Montanaro, Gregorio Monica, Filippo Cavazzini and 8 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Bruno LorussoDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-1688-7841
Antonella NogaraDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-2719-7272
Rodanthi FioretzakiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-1219-8715
Emilia CorradiniDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Roberta BoveDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0009-0008-9391-8481
Giovanni RotiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Andrea GherliDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-3643-0056
Anna MontanaroDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-5229-5395
Gregorio MonicaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0009-0000-6403-8110
Filippo CavazziniDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Sabrina BonominiHematology and BMT Unit, University Hospital of Parma, 43126 Parma, Italy.
Gallia GraianiCenter of Dental Medicine, University of Parma, 43126 Parma, Italy.
Enrico Maria SiliniPathology Section, University Hospital of Parma, 43126 Parma, Italy.ORCID 0000-0003-2578-3059
Letizia GnettiPathology Section, University Hospital of Parma, 43126 Parma, Italy.
Francesco Paolo PilatoPathology Section, University Hospital of Parma, 43126 Parma, Italy.
Giuseppe CerasoliPediatric Surgery, Ospedale dei Bambini of Parma, University Hospital of Parma, 43126 Parma, Italy.
Federico QuainiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-2377-4810
Costanza Anna Maria LagrastaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-0552-9205

Funding

University of Parma FIL 2021
6 · The paper itself

Abstract

Infantile hemangiomas (IHs) are benign vascular neoplasms of childhood (prevalence 5-10%) due to the abnormal proliferation of endothelial cells. IHs are characterized by a peculiar natural life cycle enclosing three phases: proliferative (≤12 months), involuting (≥13 months), and involuted (up to 4-7 years). The mechanisms underlying this neoplastic disease still remain uncovered. Twenty-seven IH tissue specimens (15 proliferative and 12 involuting) were subjected to hematoxylin and eosin staining and a panel of diagnostic markers by immunohistochemistry. WT1, nestin, CD133, and CD26 were also analyzed. Moreover, CD31

Indexed as

AC133 AntigenCell ProliferationDipeptidyl Peptidase 4HemangiomaVildagliptinChildChild, PreschoolDipeptidyl-Peptidase IV InhibitorsEndothelial CellsFemaleGlucose Transporter Type 1HumansInfantInfant, NewbornKi-67 AntigenMaleAC133 AntigenDipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsDPP4 protein, humanGlucose Transporter Type 1Ki-67 AntigenNES protein, humanNestinPECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1PROM1 protein, humanVildagliptinWT1 ProteinsapoptosisCD133CD26cell cycleendothelial cellsimmunohistochemistryki67p21proliferationproliferative infantile hemangioma

Identifiers

PMID39337249
PMCPMC11432178

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.