Evidence map›Paper›PMID 39337455›Full record

ArticleInternational journal of molecular sciences2024

Navigating the Intersection of Glycemic Control and Fertility: A Network Perspective.

Carlo Di Carlo, Costanza Cimini, Ramses Belda-Perez, Luca Valbonetti, Nicola Bernabò, Barbara Barboni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlo Di CarloDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0009-0009-4268-2111
Costanza CiminiDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.
Ramses Belda-PerezDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.
Luca ValbonettiDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0001-5914-615X
Nicola BernabòDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0001-5140-9656
Barbara BarboniDepartment of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-0231-8066

Funding

European Union - Next Generation EU. Project Title: Innovation, digitalization, and sustainability for the diffused economy in Central Italy - VITALITY Project Code: ECS00000041; Project CUP: C43C22000380007
6 · The paper itself

Abstract

The rising incidence of metabolic diseases is linked to elevated blood glucose levels, contributing to conditions such as diabetes and promoting the accumulation of advanced glycation end products (AGEs). AGEs, formed by non-enzymatic reactions between sugars and proteins, build up in tissues and are implicated in various diseases. This article explores the relationship between glycemic control and AGE accumulation, focusing on fertility implications. A computational model using network theory was developed, featuring a molecular database and a network with 145 nodes and 262 links, categorized as a Barabasi-Albert scale-free network. Three main subsets of nodes emerged, centered on glycemic control, fertility, and immunity, with AGEs playing a critical role. The transient receptor potential vanilloid 1 (TRPV1), a receptor expressed in several tissues including sperm, was identified as a key hub, suggesting that the modulation of TRPV1 in sperm by AGEs may influence fertility. Additionally, a novel link between glycemic control and immunity was found, indicating that immune cells may play a role in endocytosing specific AGEs. This discovery underscores the complex interplay between glycemic control and immune function, with significant implications for metabolic, immune health, and fertility.

Indexed as

FertilityGlycation End Products, AdvancedGlycemic ControlBlood GlucoseHumansMaleTRPV Cation ChannelsBlood GlucoseGlycation End Products, AdvancedTRPV Cation Channelsadvanced glycation end productsbiological networkglycemic controlimmunityinfertilityreproductionsystem biology

Identifiers

PMID39337455
PMCPMC11432572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.