Evidence map›Paper›PMID 39337514›Full record

ArticleInternational journal of molecular sciences2024

Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line.

Hans K Ghayee, Kaylie A Costa, Yiling Xu, Heather M Hatch, Mateo Rodriguez, Shelby C Straight, Marian Bustamante, Fahong Yu, Fatima Smagulova, John A Bowden and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hans K GhayeeDepartment of Medicine, Division of Endocrinology, College of Medicine, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL 32608, USA.
Kaylie A CostaDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.
Yiling XuDepartment of Medicine, Division of Endocrinology, College of Medicine, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL 32608, USA.
Heather M HatchDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.ORCID 0000-0003-3447-4688
Mateo RodriguezDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.
Shelby C StraightDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.
Marian BustamanteDepartment of Medicine, Division of Endocrinology, College of Medicine, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL 32608, USA.
Fahong YuThe Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-6670-8795
Fatima SmagulovaUniversité de Rennes, EHESP, Inserm, Irset (Institut de Recherche en Santé, Environnement et Travail), Campus Sante de Villejean-UMR_S 1085, F-35000 Rennes, France.ORCID 0000-0001-6883-1968
John A BowdenDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.
Sergei G TevosianDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 03610, USA.

Funding

Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paragangliomaR21TR003044 · NCATS · UNIVERSITY OF FLORIDA · PI GHAYEE, HANS K. · 2020 to 2021
$419k
NATL INST OF HLTH NCATS R21TR003044NCATS NIH HHS R21 TR003044SDHB PHEO PARA COALITION AWD14553
6 · The paper itself

Abstract

Pheochromocytomas (PCCs) are tumors arising from chromaffin cells in the adrenal medulla, and paragangliomas (PGLs) are tumors derived from extra-adrenal sympathetic or parasympathetic paraganglia; these tumors are collectively referred to as PPGL cancer. Treatment for PPGL primarily involves surgical removal of the tumor, and only limited options are available for treatment of the disease once it becomes metastatic. Human carriers of the heterozygous mutations in the succinate dehydrogenase subunit B (

Indexed as

Adrenal Gland NeoplasmsLipid MetabolismPheochromocytomaPolyaminesAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMicePiperidinesSuccinate DehydrogenasePiperidinesPolyaminesSDHB protein, humanSuccinate DehydrogenaseDENSPMparagangliomapheochromocytomaplasmanylSDHB

Identifiers

PMID39337514
PMCPMC11432427

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.