Evidence map›Paper›PMID 39337521›Full record

ArticleInternational journal of molecular sciences2024

L-Glutamate Regulates Npy via the mGluR4-Ca

Jiahui Duan, Qiuling Wang, Shan He, Xu-Fang Liang, Liyun Ding

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiahui DuanCollege of Fisheries, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan 430070, China.
Qiuling WangCollege of Fisheries, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan 430070, China.
Shan HeCollege of Fisheries, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan 430070, China.
Xu-Fang LiangCollege of Fisheries, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan 430070, China.
Liyun DingPoyang Lake Fisheries Research Centre of Jiangxi Province, Jiangxi Fisheries Research Institute, Nanchang 330039, China.ORCID 0000-0002-1295-2987

Funding

Fishery Seed Industry Joint Breeding Project of Jiangxi Province 2023yyzygg-02The Key Research and Development Program of Jiangxi Province 20232BBF60011
6 · The paper itself

Abstract

Metabotropic glutamate receptor 4 (mGluR4) is widely regarded as an umami receptor activated by L-glutamate to exert essential functions. Numerous studies have shown that umami receptors participate in food intake regulation. However, little is known about mGluR4's role in mediating food ingestion and its possible molecular mechanism. Mandarin fish, a typical carnivorous fish, is sensitive to umami substances and is a promising vertebrate model organism for studying the umami receptor. In this study, we identified the mGluR4 gene and conducted evolutionary analyses from diverse fish species with different feeding habits. mGluR4 of mandarin fish was cloned and functionally expressed to investigate the effects of L-glutamate on mGluR4. We further explored whether the signal pathway mGluR4-Ca

Indexed as

Fish ProteinsGlutamic AcidMAP Kinase Signaling SystemNeuropeptide YReceptors, Metabotropic GlutamateAmino Acid SequenceAnimalsCalciumFishesPerciformesPhylogenyCalciumFish ProteinsGlutamic Acidmetabotropic glutamate receptor 4Neuropeptide YReceptors, Metabotropic GlutamateCa2+ regulationERK1/2L-glutamatemandarin fish (Siniperca chuatsi)mGluR4Npy

Identifiers

PMID39337521
PMCPMC11432707

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.