Evidence mapPaperPMID 39337669Full record

ReviewInternational journal of molecular sciences2024

The Use of Autologous Cell Therapy in Diabetic Patients with Chronic Limb-Threatening Ischemia.

Dominika Sojakova, Jitka Husakova, Vladimira Fejfarova, Andrea Nemcova, Radka Jarosikova, Simon Kopp, Veronika Lovasova, Edward B Jude, Michal Dubsky

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dominika SojakovaDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.ORCID 0009-0002-3510-3993
Jitka HusakovaDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.
Vladimira FejfarovaDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.
Andrea NemcovaDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.
Radka JarosikovaDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.
Simon KoppDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.
Veronika LovasovaTransplantation Surgery Department, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.ORCID 0000-0003-2659-7725
Edward B JudeDiabetes Center, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne OL6 9RW, UK.
Michal DubskyDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.ORCID 0000-0002-2078-0177

Funding

National Institute for Research on Metabolic and Cardiovascular Diseases (Programme EXCELES, Project No. LX22NPO5104), funded by the European Union Next-Generation EU. LX22NPO5104
6 · The paper itself

Abstract

Autologous cell therapy (ACT) is primarily used in diabetic patients with chronic limb-threatening ischemia (CLTI) who are not candidates for standard revascularization. According to current research, this therapy has been shown in some studies to be effective in improving ischemia parameters, decreasing the major amputation rate, and in foot ulcer healing. This review critically evaluates the efficacy of ACT in patients with no-option CLTI, discusses the use of mononuclear and mesenchymal stem cells, and compares the route of delivery of ACT. In addition to ACT, we also describe the use of new revascularization strategies, e.g., nanodiscs, microbeads, and epigenetics, that could enhance the therapeutic effect. The main aim is to summarize new findings on subcellular and molecular levels with the clinical aspects of ACT.

Indexed as

Transplantation, AutologousCell- and Tissue-Based TherapyChronic Limb-Threatening IschemiaDiabetes MellitusHumansIschemiaMesenchymal Stem Cell Transplantationchronic limb-threatening ischemiaperipheral artery diseasestem cell therapy

Identifiers

PMID39337669
PMCPMC11431855

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.