Evidence map›Paper›PMID 39338249›Full record

ArticleJournal of personalized medicine2024

Retinal Microvascular Changes in Association with Endothelial Glycocalyx Damage and Arterial Stiffness in Patients with Diabetes Mellitus Type 2: A Cross-Sectional Study in a Greek Population.

Chrysa Agapitou, Theodoros N Sergentanis, John Thymis, George Pavlidis, Stamatios Lampsas, Emmanouil Korakas, Aikaterini Kountouri, Loukia Pliouta, Efthymios Karmiris, Areti Lagiou and 4 more

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Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chrysa Agapitou2nd Department of Ophthalmology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0009-0008-2778-9773
Theodoros N SergentanisDepartment of Public Health Policy, School of Public Health, University of West Attica, 115 21 Athens, Greece.ORCID 0000-0002-9355-5528
John Thymis2nd Department of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0002-3916-5350
George Pavlidis2nd Department of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0003-3220-3446
Stamatios Lampsas2nd Department of Ophthalmology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0001-6481-0000
Emmanouil KorakasResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0002-7813-5488
Aikaterini KountouriResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0001-5829-7327
Loukia PlioutaResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Efthymios Karmiris2nd Department of Ophthalmology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0002-4091-9236
Areti LagiouLaboratory of Hygiene and Epidemiology, Department of Public and Community Health, University of West Attica, 124 62 Athens, Greece.ORCID 0000-0002-6687-358X
Panagiotis Theodossiadis2nd Department of Ophthalmology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Vaia LambadiariResearch Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Ignatios Ikonomidis2nd Department of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0001-8241-7886
Irini Chatziralli2nd Department of Ophthalmology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0001-8523-1024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the potential association between endothelial glycocalyx damage, as well as arterial stiffness, and the retinal changes on optical coherence tomography (OCT) and OCT-angiography (OCT-A) in patients with type 2 diabetes mellitus (DM).

methodsParticipants in this cross-sectional study were 65 patients with DM type 2 and 42 age- and gender-matched controls without DM. The demographic and clinical characteristics of the participants were recorded. All patients underwent a thorough ophthalmological examination and multimodal imaging, including fundus photography, OCT, and OCT-A. In addition, evaluation of the endothelial glycocalyx thickness by measuring the perfused boundary region (PBR5-25) of the sublingual microvessel, as well as of the arterial stiffness, by measuring the carotid-femoral pulse wave velocity (PWV), the central aortic pressures and the augmentation index (Aix) was performed. Univariate and multivariate logistic regression analysis was performed for the examination of the potential association between the eye imaging variables and the cardiovascular-related variables. The odds ratios (OR) with the respective 95% confidence intervals (CI) were calculated. A

resultsPatients with DM presented significantly higher PBR5-25 compared to controls without DM (

conclusionsMarkers of endothelial damage and arterial stiffness were associated with structural and microvascular retinal alterations in patients with DM, pointing out that OCT-A could be a useful biomarker for detecting potential cardiovascular risk in such patients.

Indexed as

arterial stiffnessdiabeticendothelial dysfunctionmicrovascularOCT-A

Identifiers

PMID39338249
PMCPMC11433242

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.