Evidence map›Paper›PMID 39340069›Full record

ArticleVaccines2024

Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination.

Mia Mosavie, Jennifer Rynne, Matthew Fish, Peter Smith, Aislinn Jennings, Shivani Singh, Jonathan Millar, Heli Harvala, Ana Mora, Fotini Kaloyirou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mia MosavieCentre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.ORCID 0000-0002-8332-5948
Jennifer RynneCentre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.
Matthew FishCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-6462-3889
Peter SmithCentre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.
Aislinn JenningsCentre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.ORCID 0000-0002-6954-5717
Shivani SinghDepartment of Medicine, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London W6 8RF, UK.
Jonathan MillarCentre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.
Heli HarvalaRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Ana MoraHeart Lung Research Institute Clinical Research Facility, Cambridge CB2 0BB, UK.
Fotini KaloyirouStatistics and Clinical Research, NHS Blood and Transplant, Cambridge CB2 0PT, UK.ORCID 0000-0001-7290-6934
Alexandra GriffithsStatistics and Clinical Research, NHS Blood and Transplant, Bristol BS34 7QH, UK.
Valerie HopkinsStatistics and Clinical Research, NHS Blood and Transplant, Cambridge CB2 0PT, UK.ORCID 0000-0002-2167-1650
Charlotte WashingtonDonor Medicine, NHS Blood and Transplant, Birmingham B15 2SG, UK.
Lise J EstcourtRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0003-4309-9162
David RobertsRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Manu Shankar-HariCentre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.ORCID 0000-0002-5338-2538

Funding

Marshall Scholarship and Clarendon Fund Marshall Scholarship and Clarendon FundNational Institute for Health Research 2016-16-011National Institute of Academic Anesthesia BJA/RCoA fellowship WKRO-2018-0047NIH HHS COV19-RECPLAS
6 · The paper itself

Abstract

Molecular changes in lymphocytes following SARS-CoV-2 vaccination are incompletely understood. We hypothesized that studying the molecular (transcriptomic, epigenetic, and T cell receptor (TCR) repertoire) changes in CD4

Indexed as

CD4+ T helper cellCOVID-19epigeneticsrepertoireSARS-CoV-2T cell receptortranscriptomicsvaccination

Identifiers

PMID39340069
PMCPMC11435719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.