Evidence map›Paper›PMID 39340505›Full record

ArticleJACC. Clinical electrophysiology2024

Enhanced Ca

Xianwei Zhang, Yixuan Wu, Charlotte E R Smith, William E Louch, Stefano Morotti, Dobromir Dobrev, Eleonora Grandi, Haibo Ni

Abstract read
In one paragraph

Article in JACC. Clinical electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Xianwei ZhangDepartment of Pharmacology, University of California-Davis, Davis, California, USA. Electronic address: https://twitter.com/xianweizhang1.
Yixuan WuDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Charlotte E R SmithDepartment of Pharmacology, University of California-Davis, Davis, California, USA. Electronic address: https://twitter.com/Char_Smith3.
William E LouchInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway. Electronic address: https://twitter.com/IEMRLouch.
Stefano MorottiDepartment of Pharmacology, University of California-Davis, Davis, California, USA. Electronic address: https://twitter.com/MorottiLab.
Dobromir DobrevInstitute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany; Montréal Heart Institute, Université de Montréal, Montréal, Québec, Canada; Department of Integrative Physiology, Baylor College of Medicine, Houston, Texas, USA. Electronic address: https://twitter.com/dr_dobrev.
Eleonora GrandiDepartment of Pharmacology, University of California-Davis, Davis, California, USA. Electronic address: ele.grandi@gmail.com.
Haibo NiDepartment of Pharmacology, University of California-Davis, Davis, California, USA. Electronic address: hbni@ucdavis.edu.

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA · 2019 to 2026
$21.1M
Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5M
Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
The Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8M
Multiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VFR01HL170521 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Eleonora Grandi · 2023 to 2026
$3.1M
Resolution of inflammation and atrial fibrillationR01HL165704 · NHLBI · UNIVERSITY OF MINNESOTA · PI SAMUEL C DUDLEY · 2023 to 2026
$2.9M
Cardiac fibroblast inflammasome and atrial myopathyR01HL163277 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA · 2022 to 2025
$2.8M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
Modeling of subcellular signaling crosstalk in failing myocytesR00HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2020 to 2022
$722k
American Heart Association-American Stroke Association 20POST35120462 - HAIBO NIAmerican Heart Association-American Stroke Association 24CDA1258695NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R00 HL138160NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL136389NHLBI NIH HHS R01 HL141214NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01 HL163277NHLBI NIH HHS R01 HL165704NHLBI NIH HHS R01 HL170521NIH HHS OT2 OD026580
6 · The paper itself

Abstract

backgroundSubstantial sex-based differences have been reported in atrial fibrillation (AF), but the underlying mechanisms are poorly understood.

objectivesThis study sought to gain a mechanistic understanding of Ca

methodsWe integrated reported sex differences and AF-associated changes (ie, expression and phosphorylation of Ca

resultsSimulated quiescent cardiomyocytes showed increased incidence of Ca

conclusionsSex-specific modeling uncovers increased Ca

Indexed as

Action PotentialsAtrial FibrillationCalciumMyocytes, CardiacCalcium SignalingComputer SimulationFemaleHeart AtriaHumansMaleModels, CardiovascularRyanodine Receptor Calcium Release ChannelSex FactorsCalciumRyanodine Receptor Calcium Release Channelatrial fibrillationCa(2+)-driven arrhythmiascomputational modelingsex differencestherapy

Identifiers

PMID39340505
PMCPMC11602355

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.