Evidence map›Paper›PMID 39343293›Full record

ArticleChest2025

Airways Abnormalities in a Prospective Cohort of Patients With Rheumatoid Arthritis.

Scott M Matson, Jiwoong Choi, Drayton Rorah, Shamir Khan, Anna Trofimoff, Taewon Kim, David H Lee, Asma Abdolijomoor, Maggie Chen, Imaan Azeem and 7 more

Abstract read
In one paragraph

Article in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Lung disease in rheumatoid arthritis.Nature reviews. Rheumatology · 2026
    Review
  3. Article
  4. Rheumatoid Lung Disease.Mediterranean journal of rheumatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Scott M MatsonDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS. Electronic address: Smatson@kumc.edu.
Jiwoong ChoiDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
Drayton RorahDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS.
Shamir KhanUniversity of Kansas School of Medicine, Kansas City, KS.
Anna TrofimoffUniversity of Kansas School of Medicine, Kansas City, KS.
Taewon KimDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
David H LeeDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
Asma AbdolijomoorDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
Maggie ChenUniversity of Kansas School of Medicine, Kansas City, KS.
Imaan AzeemDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
Linh NgoDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
Tami J BangDepartment of Thoracic Radiology, National Jewish Hospital, Denver, CO.
Peter SachsDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Kevin D DeaneDivision of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
M Kristen DemoruelleDivision of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Mario CastroDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
Joyce S LeeDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Diane E Mahoney · 2019 to 2026
$21.5M
NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) affects roughly 1% of the population and commonly involves the lungs. Of lung involvement in RA, interstitial lung disease (ILD) is well known; however, airways disease in RA is relatively understudied. RESEARCH QUESTION: What are the baseline airways abnormalities in a prospective cohort of patients with RA based on pulmonary function testing (PFT) results, high-resolution CT (HRCT) scans, and computational imaging analysis and are there associations between these abnormalities and respiratory symptoms? STUDY DESIGN AND

methodsIn this single-center study, 188 patients with RA without a clinical diagnosis of ILD underwent HRCT imaging and PFT. Radiologists assessed HRCT scans for airway abnormalities. Computational imaging via VIDA Vision software and in-house quantitative CT imaging analysis was applied to 147 HRCT scans to quantify airway abnormalities.

resultsAirways obstruction (FEV

interpretationHigh rates of airways abnormalities were found in this prospective RA cohort based on three methods of detection. Significant associations were identified between quantitative CT scan measures and respiratory symptoms. Airways disease may be an underrecognized extra-articular manifestation of RA and quantitative CT imaging may be a sensitive method to detect the clinical impact on respiratory symptoms.

Indexed as

Arthritis, RheumatoidLung Diseases, InterstitialAgedFemaleHumansMaleMiddle AgedProspective StudiesRespiratory Function TestsTomography, X-Ray Computedairways diseaseasthmaCOPDquantitative CT imaging analysisrheumatoid arthritis

Identifiers

PMID39343293
PMCPMC11867896

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.