Evidence map›Paper›PMID 39343843›Full record

ArticleBulletin of experimental biology and medicine2024

Regulation of the Organic Anion Transporting Polypeptide 1B3 (OATP1B3) by Sex Hormones.

A A Slepnev, Yu V Abalenikhina, A V Shchulkin, P D Ananyeva, E N Yakusheva

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A A SlepnevRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
Yu V AbalenikhinaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
A V ShchulkinRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia. alekseyshulkin@rambler.ru.
P D AnanyevaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
E N YakushevaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms of regulation of the organic anion transporting polypeptide OATP1B3 by sex hormones were studied using HepG2 cells. Estradiol, progesterone, and testosterone were added to cells at concentrations of 1, 10, 100 μM for 24 h. The relative content of OATP1B3 was evaluated by Western blotting. Estradiol at concentrations of 10 and 100 μM increased the level of OATP1B3 acting through the farnesoid X-receptor, testosterone at concentrations of 1, 10, and 100 μM increased the expression of the transporter protein due to its effect on the liver X-receptor subtype α (LXRα), and progesterone did not affect the expression of OATP1B3.

Indexed as

EstradiolProgesteroneSolute Carrier Organic Anion Transporter Family Member 1B3TestosteroneGene Expression RegulationHep G2 CellsHumansLiver X ReceptorsEstradiolLiver X ReceptorsProgesteroneSLCO1B3 protein, humanSolute Carrier Organic Anion Transporter Family Member 1B3TestosteroneestradiolHepG2organic anion transporting polypeptide 1B3progesteronetestosterone

Identifiers

PMID39343843

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.