Evidence map›Paper›PMID 39345364›Full record

ArticlebioRxiv : the preprint server for biology2024

TRPC3 suppression ameliorates synaptic dysfunctions and memory deficits in Alzheimer's disease.

Jiaxing Wang, Ling Chen, Zhengjun Wang, Sicheng Zhang, Dongyi Ding, Geng Lin, Hua Zhang, Vijay K Boda, Dehui Kong, Tyler C Ortyl and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jiaxing WangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Ling ChenDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Zhengjun WangDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Sicheng ZhangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Dongyi DingDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Geng LinDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Hua ZhangDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Vijay K BodaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Dehui KongDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Tyler C OrtylDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Xusheng WangDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Fu-Ming ZhouDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Ilya BezprozvannyDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Jianyang DuDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.ORCID 0000-0002-4342-0975
Zhongzhi WuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Wei LiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Francesca-Fang LiaoDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.ORCID 0000-0001-5144-3600

Funding

Calcium dysregulation and vulnerability of entorhinal cortex neurons in Alzheimer's diseaseR01AG071310 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI James S Malter · 2023 to 2026
$2.9M
Novel mechanistic link between metabolic changes and dementia - potential role of miRNAsRF1AG058467 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LIAO, FRANCESCA-FANG, YUE, JUNMING · 2018 to 2018
$2.7M
CO2 inhalation enhances the lability of fear memoryR01MH113986 · NIMH · UNIVERSITY OF TOLEDO · PI DU, JIANYANG · 2018 to 2022
$1.8M
Is HSF1 the key in mediating Hsp90 inhibitor effect in AD?R01AG049772 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LIAO, FRANCESCA-FANG · 2015 to 2019
$1.4M
Validation of a novel tau clearance mechanism.R01AG072703 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Kiran Bhaskar, WEI LI · 2025 to 2026
$1.4M
Blood-brain-barrier and white matter mechanisms underlying dementiaR01NS120327 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LIAO, FRANCESCA-FANG, ZHOU, FU-MING · 2024 to 2025
$1.0M
Targeting TRPC3 Channels for Epileptic SeizuresR61NS124923 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JIANG, JIANXIONG, LI, WEI · 2022 to 2023
$765k
Sigma 1 receptor as therapeutic target for Alzheimers disease treatmentR56AG078337 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI MALTER, JAMES S · 2023 to 2023
$700k
NIA NIH HHS R01 AG049772NIA NIH HHS R01 AG071310NIA NIH HHS R01 AG072703NIA NIH HHS R56 AG078337NIA NIH HHS RF1 AG058467NIMH NIH HHS R01 MH113986NINDS NIH HHS R01 NS120327NINDS NIH HHS R61 NS124923
6 · The paper itself

Abstract

Transient receptor potential canonical (TRPC) channels are widely expressed in the brain; however, their precise roles in neurodegeneration, such as Alzheimer's disease (AD) remain elusive. Bioinformatic analysis of the published single-cell RNA-seq data collected from AD patient cohorts indicates that the

Identifiers

PMID39345364
PMCPMC11430068

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.