Evidence map›Paper›PMID 39345385›Full record

ArticlebioRxiv : the preprint server for biology2024

A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls.

Valérie Godefroy, Anais Durand, Marie-Christine Simon, Bernd Weber, Joseph Kable, Caryn Lerman, Fredrik Bergström, Richard Levy, Bénédicte Batrancourt, Liane Schmidt and 2 more

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272230 (Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System in Healthy Subject and Patient With Cerebral Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03272230 nacompletednot on this map

Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System in Healthy Subject and Patient With Cerebral Disease

TypeinterventionalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2017 to 2024Enrolled66ConditionsApathy, Behavioral Variant Frontotemporal Dementia (bvFTD), Disinhibition, Depression - Major Depressive DisorderArmsECOCAPTURE, Cognitive and Behavioral experimental tasks, Neuropsychological assessment, ICM_APATHY_TASKS, MRI
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Valérie GodefroyUniversité Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, F-69500, Bron, France.ORCID 0000-0001-8330-5413
Anais DurandParis Brain Institute (ICM), INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France UMR 7225, Sorbonne University, Paris, France.
Marie-Christine SimonInstitute for Nutrition Science, University of Bonn, Bonn, Germany.
Bernd WeberCenter for Economics and Neuroscience, University of Bonn, Bonn, Germany.
Joseph KableDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, USA.
Caryn LermanUSC Norris Comprehensive Cancer Center.
Fredrik BergströmFaculty of Psychology and Educational Sciences, University of Coimbra, Portugal.
Richard LevyParis Brain Institute (ICM), INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France UMR 7225, Sorbonne University, Paris, France.
Bénédicte BatrancourtParis Brain Institute (ICM), INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France UMR 7225, Sorbonne University, Paris, France.
Liane SchmidtParis Brain Institute (ICM), INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France UMR 7225, Sorbonne University, Paris, France.
Hilke PlassmannParis Brain Institute (ICM), INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France UMR 7225, Sorbonne University, Paris, France.
Leonie KobanUniversité Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, F-69500, Bron, France.

Funding

Neuroscience-based Interventions for Cancer Risk Behavior ChangeR35CA197461 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LERMAN, CARYN · 2015 to 2021
$6.0M
Retraining Neurocognitive Mechanisms of Cancer Risk Behavior (PQ4)R01CA170297 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KABLE, JOSEPH W, LERMAN, CARYN · 2012 to 2015
$2.0M
NCI NIH HHS R01 CA170297NCI NIH HHS R35 CA197461
6 · The paper itself

Abstract

Impulsivity and higher preference for sooner over later rewards (i.e., delay discounting) are transdiagnostic markers of many psychiatric and neurodegenerative disorders. Yet, their neurobiological basis is still debated. Here, we aimed at 1) identifying a structural MRI signature of delay discounting in healthy adults, and 2) validating it in patients with behavioral variant frontotemporal dementia (bvFTD)-a neurodegenerative disease characterized by high impulsivity. We used a machine-learning algorithm to predict individual differences in delay discounting rates based on whole-brain grey matter density maps in healthy male adults (Study 1, N=117). This resulted in a cross-validated prediction-outcome correlation of

Indexed as

brain signaturedecision-makingdelay discountingdementiaintertemporal choicemachine-learningprediction

Identifiers

PMID39345385
PMCPMC11429931

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.